Elevated serum interleukin 1 receptors and interleukin 1B in patients with Behcet's disease: Correlations with disease activity and severity

G. Yosipovitch, B. Shohat, J. Bshara, A. Wysenbeek, A. Weinberger

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Soluble interleukin 2 receptor (SIL-2R) and interleukin 1-B (IL-1B) levels in peripheral blood were assayed by enzyme-linked immunoabsorbent method in 25 patients with Behcet's disease and in 20 healthy controls. Eighteen patients suffered from active Behcet's disease and 6 patients had severe disease manifestations. SIL-2R levels were followed for a period of 16 months and were correlated with disease activity. In all the patients with Behcet's disease the levels of SIL-2R and IL-1B were significantly higher than their control, 958 ± 712 vs. 404 ± 119 u/ml (P < 0.001) for SIL-2R and 639 ± 741 vs. 59 ± 53 pg/ml (P < 0.001) for IL-1B. No correlation was found between disease activity and severity and the levels of SIL-2R and IL-1B. It is suggested that levels of SIL-2R and IL-1B are elevated in patients with Behcet's disease but do not serve as disease activity markers.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalIsrael journal of medical sciences
Volume31
Issue number6
StatePublished - 1995
Externally publishedYes

Keywords

  • Behcet's disease
  • Interleukin 1B
  • Interleukin 2
  • Receptors

ASJC Scopus subject areas

  • Bioengineering

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