Elevated red cell distribution width identifies elevated cardiovascular disease risk in patients with HIV infection

Sadeer G. Al-Kindi, Chang H. Kim, Stephen R. Morris, Michael L. Freeman, Nicholas T. Funderburg, Benigno Rodriguez, Grace A. McComsey, Jarrod E. Dalton, Daniel I. Simon, Michael M. Lederman, Chris T. Longenecker, David A. Zidar

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with HIV infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (.14.5%) is independently associated with increased risk of coronary artery disease {odds ratio [OR] 1.39 [95% confidence interval (CI): 1.25 to 1.55]}, peripheral vascular disease [OR 1.41 (95% CI: 1.29 to 1.53)], myocardial infarction [1.43 (95% CI: 1.25 to 1.63)], heart failure [OR 2.23 (95% CI: 1.99 to 2.49)], and atrial fibrillation [OR 1.96 (95% CI: 1.64 to 2.33)]. In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume74
Issue number3
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Coronary
  • Heart failure
  • Peripheral
  • RDW

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Elevated red cell distribution width identifies elevated cardiovascular disease risk in patients with HIV infection'. Together they form a unique fingerprint.

Cite this