Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias

Young J. Lee, Wenche Jy, Lawrence L. Horstman, Jamal Janania, Yolanda Reyes, Roger E. Kelley, Yeon S. Ahn

Research output: Contribution to journalArticle

210 Scopus citations

Abstract

Platelets release microparticles (PMP) upon activation. Elevated levels of PMP were observed in patients with immune thrombocytopenic purpura (ITP), sometimes associated with a syndrome resembling transient ischemic attack (TIA), suggesting a thrombogenic potential for PMP. To determine if this association applies to TIA and other cerebrovascular accidents (CVA) without ITP, we studied PMP profiles in 71 patients with ischemic CVA: 28 with small vessel CVA (SCVA), either lacunar infarcts or TIA; 24 with large vessel CVA (LCVA); 19 with multiinfarct dementia (MID); 12 with Alzheimer's dementia (AD); and 31 healthy controls. The mean PMP values were: MID = 3.71 ±0.51; SCVA = 3.48 ±0.63; LCVA = 1.97 ±0.28; AD = 1.19 ±0.27; controls = 0.88 ±0.09, (all units × 107/mL). PMP values in all groups except AD were significantly above normal (p<0.01). However, the elevation in SCVA was more marked than in LCVA (p<0.01). Administration of the calcium channel blocker, nifedipine, to 11 TIA patients reduced PMP significantly.

Original languageEnglish (US)
Pages (from-to)295-304
Number of pages10
JournalThrombosis Research
Volume72
Issue number4
DOIs
StatePublished - Nov 15 1993

Keywords

  • calcium channel blocker
  • dementias
  • lacunar infarcts
  • platelet activation
  • platelet microparticles
  • TIA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Fingerprint Dive into the research topics of 'Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias'. Together they form a unique fingerprint.

  • Cite this