Elevated Plasma Histamine Levels in Systemic Sclerosis (Scleroderma)

Vincent Falanga, Nicholas A. Soter, Roy D Altman, Francisco A. Kerdel

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Systemic sclerosis is characterized by excessive deposition of collagen and other matrix proteins in the skin and internal organs. One hypothesis supports fibroblast stimulation for production of excess amounts of collagen by factors present in the blood or released by cells composing inflammatory tissue infiltrates. Increased numbers of mast cells are present in the involved skin of patients with systemic sclerosis, and histamine has been thought to be a possible mediator of fibrosis in this and other fibrotic conditions. We therefore measured plasma histamine levels in 32 patients with systemic sclerosis and found elevated levels in 18 patients (56%). Elevated plasma histamine levels were more common in patients with diffuse disease (74%), in contrast to limited disease (31%). The degree of clinical activity and the duration of disease could not be correlated with histamine levels.

Original languageEnglish (US)
Pages (from-to)336-338
Number of pages3
JournalArchives of Dermatology
Volume126
Issue number3
DOIs
StatePublished - 1990

Fingerprint

Systemic Scleroderma
Histamine
Collagen
Skin
Mast Cells
Fibrosis
Fibroblasts
Proteins

ASJC Scopus subject areas

  • Dermatology

Cite this

Elevated Plasma Histamine Levels in Systemic Sclerosis (Scleroderma). / Falanga, Vincent; Soter, Nicholas A.; Altman, Roy D; Kerdel, Francisco A.

In: Archives of Dermatology, Vol. 126, No. 3, 1990, p. 336-338.

Research output: Contribution to journalArticle

Falanga, Vincent ; Soter, Nicholas A. ; Altman, Roy D ; Kerdel, Francisco A. / Elevated Plasma Histamine Levels in Systemic Sclerosis (Scleroderma). In: Archives of Dermatology. 1990 ; Vol. 126, No. 3. pp. 336-338.
@article{a2428b92395b4e52b07db4d1ac70a229,
title = "Elevated Plasma Histamine Levels in Systemic Sclerosis (Scleroderma)",
abstract = "Systemic sclerosis is characterized by excessive deposition of collagen and other matrix proteins in the skin and internal organs. One hypothesis supports fibroblast stimulation for production of excess amounts of collagen by factors present in the blood or released by cells composing inflammatory tissue infiltrates. Increased numbers of mast cells are present in the involved skin of patients with systemic sclerosis, and histamine has been thought to be a possible mediator of fibrosis in this and other fibrotic conditions. We therefore measured plasma histamine levels in 32 patients with systemic sclerosis and found elevated levels in 18 patients (56{\%}). Elevated plasma histamine levels were more common in patients with diffuse disease (74{\%}), in contrast to limited disease (31{\%}). The degree of clinical activity and the duration of disease could not be correlated with histamine levels.",
author = "Vincent Falanga and Soter, {Nicholas A.} and Altman, {Roy D} and Kerdel, {Francisco A.}",
year = "1990",
doi = "10.1001/archderm.1990.01670270068011",
language = "English (US)",
volume = "126",
pages = "336--338",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "3",

}

TY - JOUR

T1 - Elevated Plasma Histamine Levels in Systemic Sclerosis (Scleroderma)

AU - Falanga, Vincent

AU - Soter, Nicholas A.

AU - Altman, Roy D

AU - Kerdel, Francisco A.

PY - 1990

Y1 - 1990

N2 - Systemic sclerosis is characterized by excessive deposition of collagen and other matrix proteins in the skin and internal organs. One hypothesis supports fibroblast stimulation for production of excess amounts of collagen by factors present in the blood or released by cells composing inflammatory tissue infiltrates. Increased numbers of mast cells are present in the involved skin of patients with systemic sclerosis, and histamine has been thought to be a possible mediator of fibrosis in this and other fibrotic conditions. We therefore measured plasma histamine levels in 32 patients with systemic sclerosis and found elevated levels in 18 patients (56%). Elevated plasma histamine levels were more common in patients with diffuse disease (74%), in contrast to limited disease (31%). The degree of clinical activity and the duration of disease could not be correlated with histamine levels.

AB - Systemic sclerosis is characterized by excessive deposition of collagen and other matrix proteins in the skin and internal organs. One hypothesis supports fibroblast stimulation for production of excess amounts of collagen by factors present in the blood or released by cells composing inflammatory tissue infiltrates. Increased numbers of mast cells are present in the involved skin of patients with systemic sclerosis, and histamine has been thought to be a possible mediator of fibrosis in this and other fibrotic conditions. We therefore measured plasma histamine levels in 32 patients with systemic sclerosis and found elevated levels in 18 patients (56%). Elevated plasma histamine levels were more common in patients with diffuse disease (74%), in contrast to limited disease (31%). The degree of clinical activity and the duration of disease could not be correlated with histamine levels.

UR - http://www.scopus.com/inward/record.url?scp=0025238491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025238491&partnerID=8YFLogxK

U2 - 10.1001/archderm.1990.01670270068011

DO - 10.1001/archderm.1990.01670270068011

M3 - Article

C2 - 2310207

AN - SCOPUS:0025238491

VL - 126

SP - 336

EP - 338

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 3

ER -