Elevated plasma endothelial microparticles in preeclampsia.

Vctor H. González-Quintero, Joaqun J. Jiménez, Wenche Jy, Luca M. Mauro, Lawrence Hortman, Mary J. O'Sullivan, Yeon Ahn

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Abstract

OBJECTIVE: The purpose of this study was to assess endothelial dysfunction in women with preeclampsia by measuring endothelial microparticles. STUDY DESIGN: A case-control study was conducted on 20 women with preeclampsia and 20 healthy pregnant women as control subjects. Endothelial microparticles were measured by flow cytometry with anti-CD31 and anti-CD42. CD31(+)/CD42(+) platelet microparticles were also quantified. RESULTS: Plasma endothelial microparticles levels were elevated significantly in women with preeclampsia as compared with control subjects (mean+/-SD and median [range]: 14,723+/-7,724 counts/microL and 12,378 counts/microL [1,442-33,772 counts/microL] vs 8406+/-2832 counts/microL and 9016 counts/microL [3,381-12,806 counts/microL]; P<.001). Plasma platelet microparticles levels were not different among cases compared to control subjects (10,751+/-6,114 counts/microL and 9463 counts/microL [3,000-23,895 counts/microL] vs 7871+/-4344 counts/microL and 6462 counts/microL [444-18,947 counts/microL]; P=.208). No significant correlation was found between plasma endothelial microparticles and mean arterial pressure in cases or control subjects. CONCLUSION: The elevation of endothelial microparticles in women with preeclampsia supports the endothelial injury theory in preeclampsia.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume189
Issue number2
DOIs
StatePublished - Aug 2003

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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