Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes

Rossana M. Calderon, Sylvia Diaz, Angela Szeto, Jose A. Llinas, Thomas A. Hughes, Armando J Mendez, Ronald B Goldberg

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

CONTEXT: Increased high-density lipoprotein cholesterol (HDL-C) is common in type 1 diabetes (T1D) and is associated both with hyperadiponectinemia and with elevated lipoprotein lipase activity (LPL). Because adiponectin has been shown to increase LPL expression, elevated LPL may link the hyperadiponectinemia in T1D with increased HDL.

OBJECTIVE: The purpose of this study was to determine whether LPL activity accounts for the association between adiponectin and HDL in T1D.

DESIGN, PARTICIPANTS, AND SETTING: A cohort of 127 patients with T1D attending the Diabetes Clinic at the University of Miami and 103 healthy control subjects were recruited.

MAIN OUTCOME MEASURE: HDL-C and adiponectin were measured in the full cohort and in a subgroup, HDL subfractions were obtained by ultracentrifugation, and LPL and hepatic lipase were measured in postheparin plasma.

RESULTS: Total HDL-C and the lowest density HDL subfraction, apolipoprotein A-I, LPL activity, and adiponectin levels were higher in subjects with T1D than in control subjects (P <.05). Both adiponectin and LPL activity were directly associated with total HDL-C and its lowest density subfraction, but adiponectin and LPL were not correlated (P = 0.13). Adiponectin alone explained 11.6% and adiponectin plus LPL explained 23.8% of the HDL-C variance. In a multivariate model, adiponectin remained an independent predictor of HDL-C along with LPL and serum creatinine, explaining together 27% of HDL-C variance.

CONCLUSIONS: Adiponectin was strongly associated with HDL-C in T1D, suggesting that hyperadiponectinemia is linked to the elevated HDL-C in this population. However, this relationship is independent of the association between LPL and HDL-C. Thus, elevated adiponectin and LPL activity are independently related to increased HDL-C in T1D.

Original languageEnglish (US)
Pages (from-to)2581-2588
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number7
DOIs
StatePublished - Jul 1 2015

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Lipoprotein Lipase
Adiponectin
Medical problems
Type 1 Diabetes Mellitus
HDL Cholesterol
Ultracentrifugation
Apolipoprotein A-I
Lipase
Creatinine
Healthy Volunteers

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes. / Calderon, Rossana M.; Diaz, Sylvia; Szeto, Angela; Llinas, Jose A.; Hughes, Thomas A.; Mendez, Armando J; Goldberg, Ronald B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 7, 01.07.2015, p. 2581-2588.

Research output: Contribution to journalArticle

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title = "Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes",
abstract = "CONTEXT: Increased high-density lipoprotein cholesterol (HDL-C) is common in type 1 diabetes (T1D) and is associated both with hyperadiponectinemia and with elevated lipoprotein lipase activity (LPL). Because adiponectin has been shown to increase LPL expression, elevated LPL may link the hyperadiponectinemia in T1D with increased HDL.OBJECTIVE: The purpose of this study was to determine whether LPL activity accounts for the association between adiponectin and HDL in T1D.DESIGN, PARTICIPANTS, AND SETTING: A cohort of 127 patients with T1D attending the Diabetes Clinic at the University of Miami and 103 healthy control subjects were recruited.MAIN OUTCOME MEASURE: HDL-C and adiponectin were measured in the full cohort and in a subgroup, HDL subfractions were obtained by ultracentrifugation, and LPL and hepatic lipase were measured in postheparin plasma.RESULTS: Total HDL-C and the lowest density HDL subfraction, apolipoprotein A-I, LPL activity, and adiponectin levels were higher in subjects with T1D than in control subjects (P <.05). Both adiponectin and LPL activity were directly associated with total HDL-C and its lowest density subfraction, but adiponectin and LPL were not correlated (P = 0.13). Adiponectin alone explained 11.6{\%} and adiponectin plus LPL explained 23.8{\%} of the HDL-C variance. In a multivariate model, adiponectin remained an independent predictor of HDL-C along with LPL and serum creatinine, explaining together 27{\%} of HDL-C variance.CONCLUSIONS: Adiponectin was strongly associated with HDL-C in T1D, suggesting that hyperadiponectinemia is linked to the elevated HDL-C in this population. However, this relationship is independent of the association between LPL and HDL-C. Thus, elevated adiponectin and LPL activity are independently related to increased HDL-C in T1D.",
author = "Calderon, {Rossana M.} and Sylvia Diaz and Angela Szeto and Llinas, {Jose A.} and Hughes, {Thomas A.} and Mendez, {Armando J} and Goldberg, {Ronald B}",
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T1 - Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes

AU - Calderon, Rossana M.

AU - Diaz, Sylvia

AU - Szeto, Angela

AU - Llinas, Jose A.

AU - Hughes, Thomas A.

AU - Mendez, Armando J

AU - Goldberg, Ronald B

PY - 2015/7/1

Y1 - 2015/7/1

N2 - CONTEXT: Increased high-density lipoprotein cholesterol (HDL-C) is common in type 1 diabetes (T1D) and is associated both with hyperadiponectinemia and with elevated lipoprotein lipase activity (LPL). Because adiponectin has been shown to increase LPL expression, elevated LPL may link the hyperadiponectinemia in T1D with increased HDL.OBJECTIVE: The purpose of this study was to determine whether LPL activity accounts for the association between adiponectin and HDL in T1D.DESIGN, PARTICIPANTS, AND SETTING: A cohort of 127 patients with T1D attending the Diabetes Clinic at the University of Miami and 103 healthy control subjects were recruited.MAIN OUTCOME MEASURE: HDL-C and adiponectin were measured in the full cohort and in a subgroup, HDL subfractions were obtained by ultracentrifugation, and LPL and hepatic lipase were measured in postheparin plasma.RESULTS: Total HDL-C and the lowest density HDL subfraction, apolipoprotein A-I, LPL activity, and adiponectin levels were higher in subjects with T1D than in control subjects (P <.05). Both adiponectin and LPL activity were directly associated with total HDL-C and its lowest density subfraction, but adiponectin and LPL were not correlated (P = 0.13). Adiponectin alone explained 11.6% and adiponectin plus LPL explained 23.8% of the HDL-C variance. In a multivariate model, adiponectin remained an independent predictor of HDL-C along with LPL and serum creatinine, explaining together 27% of HDL-C variance.CONCLUSIONS: Adiponectin was strongly associated with HDL-C in T1D, suggesting that hyperadiponectinemia is linked to the elevated HDL-C in this population. However, this relationship is independent of the association between LPL and HDL-C. Thus, elevated adiponectin and LPL activity are independently related to increased HDL-C in T1D.

AB - CONTEXT: Increased high-density lipoprotein cholesterol (HDL-C) is common in type 1 diabetes (T1D) and is associated both with hyperadiponectinemia and with elevated lipoprotein lipase activity (LPL). Because adiponectin has been shown to increase LPL expression, elevated LPL may link the hyperadiponectinemia in T1D with increased HDL.OBJECTIVE: The purpose of this study was to determine whether LPL activity accounts for the association between adiponectin and HDL in T1D.DESIGN, PARTICIPANTS, AND SETTING: A cohort of 127 patients with T1D attending the Diabetes Clinic at the University of Miami and 103 healthy control subjects were recruited.MAIN OUTCOME MEASURE: HDL-C and adiponectin were measured in the full cohort and in a subgroup, HDL subfractions were obtained by ultracentrifugation, and LPL and hepatic lipase were measured in postheparin plasma.RESULTS: Total HDL-C and the lowest density HDL subfraction, apolipoprotein A-I, LPL activity, and adiponectin levels were higher in subjects with T1D than in control subjects (P <.05). Both adiponectin and LPL activity were directly associated with total HDL-C and its lowest density subfraction, but adiponectin and LPL were not correlated (P = 0.13). Adiponectin alone explained 11.6% and adiponectin plus LPL explained 23.8% of the HDL-C variance. In a multivariate model, adiponectin remained an independent predictor of HDL-C along with LPL and serum creatinine, explaining together 27% of HDL-C variance.CONCLUSIONS: Adiponectin was strongly associated with HDL-C in T1D, suggesting that hyperadiponectinemia is linked to the elevated HDL-C in this population. However, this relationship is independent of the association between LPL and HDL-C. Thus, elevated adiponectin and LPL activity are independently related to increased HDL-C in T1D.

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DO - 10.1210/jc.2015-1357

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