Elevated Levels of Immunoglobulins and Immune Complexes in the Bile of Patients with Primary Sclerosing Cholangitis

Juan J. Alberti‐Flor, Maria de Medina, Lennox Jeffers, Duane R. Schultz, Eugene R. Schiff

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The concentration of immunoglobulins and immune complexes was determined in the serum and bile of four patients with primary sclerosing cholangitis, only one of whom had chronic ulcerative colitis, and in four postcholecystectomy control patients. The result of the immunoglobulin studies demonstrated increased serum levels of IgM in primary sclerosing cholangitis as compared to control patients. The IgG, IgA, and IgM in bile were all significantly elevated as compared to controls (p = 0.02). Immune complexes in bile and serum were also determined in both groups by the C1q and conglutinin binding assays. Immune complexes in bile were elevated in three of four of the patients with primary sclerosing cholangitis. These findings further characterize primary sclerosing cholangitis in terms of biliary immunoglobulins and immune complexes but do not resolve whether these changes are an epiphenomenon or reflect a primary role of immunoglobulins and immune complexes in the pathogenesis of this disorder.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalThe American journal of gastroenterology
Volume81
Issue number5
DOIs
StatePublished - May 1986

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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