Abstract
The goal of this study was to investigate lactate and pH distributions in subacutely and chronically infarcted human brains. Magnetic resonance spectroscopic imaging (MRSI) was used to map spatial distributions of 1H and 31P metabolites in 11 nonhemorrhagic subacute to chronic cerebral infarction patients and 11 controls. All six infarcts containing lactate were alkalotic (pHi = 7.20 ± 0.04 vs. 7.05 ± 0.01 contralateral, p < 0.01). This finding of elevated lactate and alkalosis in chronic infarctions does not support the presence of chronic ischemia; however, it is consistent with the presence of phagocytic cells, gliosis, altered buffering mechanisms, and/or luxury perfusion. Total 1H and 31P metabolites were markedly reduced (about 50% on average) in subacute and chronic brain infarctions (p < 0.01), and N-acetyl aspartate (NAA) was reduced more (∼75) than other metabolites (p < 0.01). Because NAA is localized in neurons, selective NAA reduction is consistent with pathological findings of a greater loss of neurent than glial cells in chronic infarctions.
| Original language | English |
|---|---|
| Pages (from-to) | 734-744 |
| Number of pages | 11 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 12 |
| Issue number | 5 |
| State | Published - Dec 1 1992 |
| Externally published | Yes |
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Keywords
- Alkalosis
- Brain infarction
- Hydrogen metabolism
- Lactate
- Magnetic resonance spectroscopic imaging
- Phosphorus metabolism
ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
- Endocrinology, Diabetes and Metabolism
Cite this
Elevated lactate and alkalosis in chronic human brain infarction observed by1H and31P MR spectroscopic imaging. / Hugg, James W.; Duijn, Jeff H.; Matson, Gerald B.; Maudsley, Andrew A; Tsuruda, Jay S.; Gelinas, Deborah F.; Weiner, Michael W.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 12, No. 5, 01.12.1992, p. 734-744.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevated lactate and alkalosis in chronic human brain infarction observed by1H and31P MR spectroscopic imaging
AU - Hugg, James W.
AU - Duijn, Jeff H.
AU - Matson, Gerald B.
AU - Maudsley, Andrew A
AU - Tsuruda, Jay S.
AU - Gelinas, Deborah F.
AU - Weiner, Michael W.
PY - 1992/12/1
Y1 - 1992/12/1
N2 - The goal of this study was to investigate lactate and pH distributions in subacutely and chronically infarcted human brains. Magnetic resonance spectroscopic imaging (MRSI) was used to map spatial distributions of 1H and 31P metabolites in 11 nonhemorrhagic subacute to chronic cerebral infarction patients and 11 controls. All six infarcts containing lactate were alkalotic (pHi = 7.20 ± 0.04 vs. 7.05 ± 0.01 contralateral, p < 0.01). This finding of elevated lactate and alkalosis in chronic infarctions does not support the presence of chronic ischemia; however, it is consistent with the presence of phagocytic cells, gliosis, altered buffering mechanisms, and/or luxury perfusion. Total 1H and 31P metabolites were markedly reduced (about 50% on average) in subacute and chronic brain infarctions (p < 0.01), and N-acetyl aspartate (NAA) was reduced more (∼75) than other metabolites (p < 0.01). Because NAA is localized in neurons, selective NAA reduction is consistent with pathological findings of a greater loss of neurent than glial cells in chronic infarctions.
AB - The goal of this study was to investigate lactate and pH distributions in subacutely and chronically infarcted human brains. Magnetic resonance spectroscopic imaging (MRSI) was used to map spatial distributions of 1H and 31P metabolites in 11 nonhemorrhagic subacute to chronic cerebral infarction patients and 11 controls. All six infarcts containing lactate were alkalotic (pHi = 7.20 ± 0.04 vs. 7.05 ± 0.01 contralateral, p < 0.01). This finding of elevated lactate and alkalosis in chronic infarctions does not support the presence of chronic ischemia; however, it is consistent with the presence of phagocytic cells, gliosis, altered buffering mechanisms, and/or luxury perfusion. Total 1H and 31P metabolites were markedly reduced (about 50% on average) in subacute and chronic brain infarctions (p < 0.01), and N-acetyl aspartate (NAA) was reduced more (∼75) than other metabolites (p < 0.01). Because NAA is localized in neurons, selective NAA reduction is consistent with pathological findings of a greater loss of neurent than glial cells in chronic infarctions.
KW - Alkalosis
KW - Brain infarction
KW - Hydrogen metabolism
KW - Lactate
KW - Magnetic resonance spectroscopic imaging
KW - Phosphorus metabolism
UR - http://www.scopus.com/inward/record.url?scp=0026728178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026728178&partnerID=8YFLogxK
M3 - Article
C2 - 1506441
AN - SCOPUS:0026728178
VL - 12
SP - 734
EP - 744
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 5
ER -