Abstract
Posttransplant erythrocytosis (PTE) poses a potential risk of thrombosis in kidney transplantation. Clinical observation of our systemically drained simultaneous kidney pancreas transplant (S-SPK) patients showed a higher incidence of PTE and need for phlebotomies. To evaluate the incidence of PTE we analyzed hematocrit (Hct) levels and frequency of phlebotomies in 94 SPK as compared to 174 living donor (LD) recipients and 53 type-I diabetic with kidney transplant only. For study purposes we defined PTE as Hct >50% or the necessity for phlebotomies. Kaplan-Meier plots and Cox proportional hazard models were used to examine the association between the transplant type and PTE. We found an increased incidence of PTE in SPK compared to LD (p < 0.001). In the multivariate model, SPK had a 5-fold risk for the development of PTE (AHR 5.3, 95% CI 1.8, 15.9). The incidence of therapeutic phlebotomy was 13% among SPK patients and 4% in LD kidney recipients; 19 patients altogether. A total of 64 units were phlebotomized (48-SPK and 16-LD). Type I diabetic patients with a kidney transplant showed a 0% incidence of PTE. We observed a greater incidence of PTE and phlebotomies in S-SPK compared to LD with kidney only transplant recipients.
| Original language | English |
|---|---|
| Pages (from-to) | 938-942 |
| Number of pages | 5 |
| Journal | American Journal of Transplantation |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2010 |
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Keywords
- Kidney transplantation
- Pancreas transplantation
- Polycythemia
- Post transplant erythrocytosis
ASJC Scopus subject areas
- Transplantation
- Immunology and Allergy
- Pharmacology (medical)
Cite this
Elevated incidence of posttransplant erythrocytosis after simultaneous pancreas kidney transplantation. / Guerra, Giselle; Indahyung, R.; Bucci, C. M.; Schold, J. D.; Magliocca, J. F.; Meier-Kriesche, H. U.
In: American Journal of Transplantation, Vol. 10, No. 4, 01.04.2010, p. 938-942.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevated incidence of posttransplant erythrocytosis after simultaneous pancreas kidney transplantation
AU - Guerra, Giselle
AU - Indahyung, R.
AU - Bucci, C. M.
AU - Schold, J. D.
AU - Magliocca, J. F.
AU - Meier-Kriesche, H. U.
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Posttransplant erythrocytosis (PTE) poses a potential risk of thrombosis in kidney transplantation. Clinical observation of our systemically drained simultaneous kidney pancreas transplant (S-SPK) patients showed a higher incidence of PTE and need for phlebotomies. To evaluate the incidence of PTE we analyzed hematocrit (Hct) levels and frequency of phlebotomies in 94 SPK as compared to 174 living donor (LD) recipients and 53 type-I diabetic with kidney transplant only. For study purposes we defined PTE as Hct >50% or the necessity for phlebotomies. Kaplan-Meier plots and Cox proportional hazard models were used to examine the association between the transplant type and PTE. We found an increased incidence of PTE in SPK compared to LD (p < 0.001). In the multivariate model, SPK had a 5-fold risk for the development of PTE (AHR 5.3, 95% CI 1.8, 15.9). The incidence of therapeutic phlebotomy was 13% among SPK patients and 4% in LD kidney recipients; 19 patients altogether. A total of 64 units were phlebotomized (48-SPK and 16-LD). Type I diabetic patients with a kidney transplant showed a 0% incidence of PTE. We observed a greater incidence of PTE and phlebotomies in S-SPK compared to LD with kidney only transplant recipients.
AB - Posttransplant erythrocytosis (PTE) poses a potential risk of thrombosis in kidney transplantation. Clinical observation of our systemically drained simultaneous kidney pancreas transplant (S-SPK) patients showed a higher incidence of PTE and need for phlebotomies. To evaluate the incidence of PTE we analyzed hematocrit (Hct) levels and frequency of phlebotomies in 94 SPK as compared to 174 living donor (LD) recipients and 53 type-I diabetic with kidney transplant only. For study purposes we defined PTE as Hct >50% or the necessity for phlebotomies. Kaplan-Meier plots and Cox proportional hazard models were used to examine the association between the transplant type and PTE. We found an increased incidence of PTE in SPK compared to LD (p < 0.001). In the multivariate model, SPK had a 5-fold risk for the development of PTE (AHR 5.3, 95% CI 1.8, 15.9). The incidence of therapeutic phlebotomy was 13% among SPK patients and 4% in LD kidney recipients; 19 patients altogether. A total of 64 units were phlebotomized (48-SPK and 16-LD). Type I diabetic patients with a kidney transplant showed a 0% incidence of PTE. We observed a greater incidence of PTE and phlebotomies in S-SPK compared to LD with kidney only transplant recipients.
KW - Kidney transplantation
KW - Pancreas transplantation
KW - Polycythemia
KW - Post transplant erythrocytosis
UR - http://www.scopus.com/inward/record.url?scp=77949787814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949787814&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2010.03012.x
DO - 10.1111/j.1600-6143.2010.03012.x
M3 - Article
VL - 10
SP - 938
EP - 942
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 4
ER -