Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients

Charles B. Nemeroff, Erik Widerlöv, Garth Bissette, Helena Walléus, Ingvar Karlsson, Kurt Eklund, Clinton D. Kilts, Peter T. Loosen, Wylie Vale

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Abstract

The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major depression was investigated by measuring the concentration of this peptide in cerebrospinal fluid of normal healthy volunteers in drug-free patients with DSM-III diagnoses of major depression, schizophrenia, or dementia. When compared to the controls and the other diagnostic groups, the patients with major depression showed significantly increased cerebrospinal fluid concentrations of CRF-like immunoreactivity; in 11 of the 23 depressed patients this immunoreactivity was greater than the highest value in the normal controls. These findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.

Original languageEnglish (US)
Pages (from-to)1342-1344
Number of pages3
JournalScience
Volume226
Issue number4680
DOIs
StatePublished - 1984

ASJC Scopus subject areas

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    Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984). Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science, 226(4680), 1342-1344. https://doi.org/10.1126/science.6334362