Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53

Richard J Cote, Matthew D. Dunn, Sunanda J. Chatterjee, John P. Stein, Shan Rong Shi, Quoc Chau Tran, Shi Xue Hu, Hong Ji Xu, Susan Groshen, Clive R. Taylor, Donald G. Skinner, William F. Benedict

Research output: Contribution to journalArticle

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Abstract

Rb protein (pRb) expression was evaluated in 185 cases of transitional cell carcinoma of the bladder from patients that underwent radical cystectomy. Tumors were stratified into three categories based on the percentage of nuclei expressing pRb: (a) 0, 0% of tumor cells showing nuclear reactivity; (b) 1+, 1-50% of tumor cells showing nuclear reactivity; and (c) 2+, >50% of tumor cells showing nuclear reactivity. Cases with undetectable (pRb 0) and high (pRb 2+) pRb reactivity had identical rates of recurrence. These cases had significantly higher recurrence (P = 0.0001) and lower survival rates (P = 0.0002) compared to cases with moderate (pRb 1+) pRb reactivity, indicating that high levels of pRb expression may reflect a dysfunctional (altered) Rb pathway. The tumors were also examined for alterations in p53 expression; patients with tumors altered in both p53 and pRb had significantly increased rates of recurrence (P < 0.0001) and survival (P < 0.0001) compared to patients with no alterations in either p53 or pRb; patients with alterations in only one of these proteins had intermediate rates of recurrence and survival. These results suggest that: (a) bladder cancers with high pRb expression do not show the tumor suppressor effects of the protein; and (b) alteration in both p53 and pRb may act in cooperative or synergistic ways to promote tumor progression.

Original languageEnglish
Pages (from-to)1090-1094
Number of pages5
JournalCancer Research
Volume58
Issue number6
StatePublished - Mar 15 1998
Externally publishedYes

Fingerprint

Urinary Bladder Neoplasms
Neoplasms
Recurrence
Survival Rate
Tumor Suppressor Proteins
Retinoblastoma Protein
Transitional Cell Carcinoma
Cystectomy
Urinary Bladder
Survival
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cote, R. J., Dunn, M. D., Chatterjee, S. J., Stein, J. P., Shi, S. R., Tran, Q. C., ... Benedict, W. F. (1998). Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53. Cancer Research, 58(6), 1090-1094.

Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53. / Cote, Richard J; Dunn, Matthew D.; Chatterjee, Sunanda J.; Stein, John P.; Shi, Shan Rong; Tran, Quoc Chau; Hu, Shi Xue; Xu, Hong Ji; Groshen, Susan; Taylor, Clive R.; Skinner, Donald G.; Benedict, William F.

In: Cancer Research, Vol. 58, No. 6, 15.03.1998, p. 1090-1094.

Research output: Contribution to journalArticle

Cote, RJ, Dunn, MD, Chatterjee, SJ, Stein, JP, Shi, SR, Tran, QC, Hu, SX, Xu, HJ, Groshen, S, Taylor, CR, Skinner, DG & Benedict, WF 1998, 'Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53', Cancer Research, vol. 58, no. 6, pp. 1090-1094.
Cote, Richard J ; Dunn, Matthew D. ; Chatterjee, Sunanda J. ; Stein, John P. ; Shi, Shan Rong ; Tran, Quoc Chau ; Hu, Shi Xue ; Xu, Hong Ji ; Groshen, Susan ; Taylor, Clive R. ; Skinner, Donald G. ; Benedict, William F. / Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53. In: Cancer Research. 1998 ; Vol. 58, No. 6. pp. 1090-1094.
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