TY - JOUR
T1 - Elemental composition in the pancreatic b cell is normal in the prediabetic Chinese hamster
AU - Juntti-Berggren, Lisa
AU - Lindh, Ulf
AU - Berggren, Per Olof
AU - Frankel, Barbara J.
PY - 1992/1
Y1 - 1992/1
N2 - To clarify whether elemental changes are present before the onset of diabetes, freeze-dried pancreas sections from young (18-19 days-old), genetically prediabetic Chinese hamsters were subjected to proton bombardment and the concentrations of 15 elements (Na, Mg, Al, P, S, Cl, K, Ca, Mn, Fe, Cu, Zn, Rb, Cd, and Pb) in B cells and exocrine pancreas were calculated from the x-rays emitted. We have previously shown that islet B cells and exocrine pancreas from adult, overtly diabetic Chinese hamsters contain subnormal levels of Al (-61%, -88%) and excess levels of Cu (+92%, +59%), Rb (+13%, +13%), and Mg (+6%, +6%) in B cells and exocrine pancreas, respectively (Juntti-Berggren et al., Biosci Rep 1976;7:33-41). In the present study the prediabetic B cells contained normal levels of all 15 elements, whereas the prediabetic exocrine pancreas contained a subnormal level of Fe (-10%; p < 0.005). Hence, the development of diabetes in the Chinese hamster does not seem to be associated with an early change in the elemental composition of the pancreatic B cells. In fact, the overt diabetic condition may cause changes in the body's handling of some elements.
AB - To clarify whether elemental changes are present before the onset of diabetes, freeze-dried pancreas sections from young (18-19 days-old), genetically prediabetic Chinese hamsters were subjected to proton bombardment and the concentrations of 15 elements (Na, Mg, Al, P, S, Cl, K, Ca, Mn, Fe, Cu, Zn, Rb, Cd, and Pb) in B cells and exocrine pancreas were calculated from the x-rays emitted. We have previously shown that islet B cells and exocrine pancreas from adult, overtly diabetic Chinese hamsters contain subnormal levels of Al (-61%, -88%) and excess levels of Cu (+92%, +59%), Rb (+13%, +13%), and Mg (+6%, +6%) in B cells and exocrine pancreas, respectively (Juntti-Berggren et al., Biosci Rep 1976;7:33-41). In the present study the prediabetic B cells contained normal levels of all 15 elements, whereas the prediabetic exocrine pancreas contained a subnormal level of Fe (-10%; p < 0.005). Hence, the development of diabetes in the Chinese hamster does not seem to be associated with an early change in the elemental composition of the pancreatic B cells. In fact, the overt diabetic condition may cause changes in the body's handling of some elements.
KW - Chinese hamster
KW - Diabetes mellitus
KW - Elemental composition
KW - Exocrine pancreas
KW - Pancreatic B cell
KW - Plasma insulin
KW - Proton microprobe analysis
UR - http://www.scopus.com/inward/record.url?scp=0026555133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026555133&partnerID=8YFLogxK
U2 - 10.1097/00006676-199201000-00002
DO - 10.1097/00006676-199201000-00002
M3 - Article
C2 - 1557338
AN - SCOPUS:0026555133
VL - 7
SP - 11
EP - 14
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 1
ER -