Electroretinographic changes in aged pigeons

Vittorio Porciatti, W. Hodos, G. Signorini, F. Bramanti

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Photopic electroretinograms, either to full-field light flashes (FERGs) or to contrast-reversal of square-wave gratings (PERGs) have been recorded in pigeons aged 2 years old (n = 5) and 10 years old (n = 5). Mydriatic pupil diameter, ophthalmoscopic appearance of the retinal fundus and optic media, and refractive state were comparable in the two groups. V log I functions of individual FERG components (a-wave, b-wave and oscillatory potentials) displayed significantly lower slopes in the old birds than in the young, which suggests a reduction in retinal gain. PERG amplitude also was significantly lower in the older birds over a wide range of spatial frequencies (0.2-8.8 c/deg). Estimated visual acuity based on the extrapolated high-frequency cut off was 18 c/deg in the younger birds and 7.8 c/deg in the older birds. These results are in agreement with psychophysical data and retinal age-related losses in visual acuity, photoreceptors and retinal ganglion cells. Since these findings are comparable to those reported for humans, the results suggest that pigeons may serve as a useful model for human visual aging.

Original languageEnglish
Pages (from-to)661-668
Number of pages8
JournalVision Research
Volume31
Issue number4
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Columbidae
Birds
Visual Acuity
Mydriatics
Retinal Ganglion Cells
Pupil
Light

Keywords

  • Age
  • ERG
  • Flash
  • Pattern
  • Pigeons
  • Retina
  • Tectal evoked potential

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Electroretinographic changes in aged pigeons. / Porciatti, Vittorio; Hodos, W.; Signorini, G.; Bramanti, F.

In: Vision Research, Vol. 31, No. 4, 01.01.1991, p. 661-668.

Research output: Contribution to journalArticle

Porciatti, V, Hodos, W, Signorini, G & Bramanti, F 1991, 'Electroretinographic changes in aged pigeons', Vision Research, vol. 31, no. 4, pp. 661-668. https://doi.org/10.1016/0042-6989(91)90007-R
Porciatti, Vittorio ; Hodos, W. ; Signorini, G. ; Bramanti, F. / Electroretinographic changes in aged pigeons. In: Vision Research. 1991 ; Vol. 31, No. 4. pp. 661-668.
@article{5747a74d0a7940f986e780e5b5decb5c,
title = "Electroretinographic changes in aged pigeons",
abstract = "Photopic electroretinograms, either to full-field light flashes (FERGs) or to contrast-reversal of square-wave gratings (PERGs) have been recorded in pigeons aged 2 years old (n = 5) and 10 years old (n = 5). Mydriatic pupil diameter, ophthalmoscopic appearance of the retinal fundus and optic media, and refractive state were comparable in the two groups. V log I functions of individual FERG components (a-wave, b-wave and oscillatory potentials) displayed significantly lower slopes in the old birds than in the young, which suggests a reduction in retinal gain. PERG amplitude also was significantly lower in the older birds over a wide range of spatial frequencies (0.2-8.8 c/deg). Estimated visual acuity based on the extrapolated high-frequency cut off was 18 c/deg in the younger birds and 7.8 c/deg in the older birds. These results are in agreement with psychophysical data and retinal age-related losses in visual acuity, photoreceptors and retinal ganglion cells. Since these findings are comparable to those reported for humans, the results suggest that pigeons may serve as a useful model for human visual aging.",
keywords = "Age, ERG, Flash, Pattern, Pigeons, Retina, Tectal evoked potential",
author = "Vittorio Porciatti and W. Hodos and G. Signorini and F. Bramanti",
year = "1991",
month = "1",
day = "1",
doi = "10.1016/0042-6989(91)90007-R",
language = "English",
volume = "31",
pages = "661--668",
journal = "Vision Research",
issn = "0042-6989",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Electroretinographic changes in aged pigeons

AU - Porciatti, Vittorio

AU - Hodos, W.

AU - Signorini, G.

AU - Bramanti, F.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Photopic electroretinograms, either to full-field light flashes (FERGs) or to contrast-reversal of square-wave gratings (PERGs) have been recorded in pigeons aged 2 years old (n = 5) and 10 years old (n = 5). Mydriatic pupil diameter, ophthalmoscopic appearance of the retinal fundus and optic media, and refractive state were comparable in the two groups. V log I functions of individual FERG components (a-wave, b-wave and oscillatory potentials) displayed significantly lower slopes in the old birds than in the young, which suggests a reduction in retinal gain. PERG amplitude also was significantly lower in the older birds over a wide range of spatial frequencies (0.2-8.8 c/deg). Estimated visual acuity based on the extrapolated high-frequency cut off was 18 c/deg in the younger birds and 7.8 c/deg in the older birds. These results are in agreement with psychophysical data and retinal age-related losses in visual acuity, photoreceptors and retinal ganglion cells. Since these findings are comparable to those reported for humans, the results suggest that pigeons may serve as a useful model for human visual aging.

AB - Photopic electroretinograms, either to full-field light flashes (FERGs) or to contrast-reversal of square-wave gratings (PERGs) have been recorded in pigeons aged 2 years old (n = 5) and 10 years old (n = 5). Mydriatic pupil diameter, ophthalmoscopic appearance of the retinal fundus and optic media, and refractive state were comparable in the two groups. V log I functions of individual FERG components (a-wave, b-wave and oscillatory potentials) displayed significantly lower slopes in the old birds than in the young, which suggests a reduction in retinal gain. PERG amplitude also was significantly lower in the older birds over a wide range of spatial frequencies (0.2-8.8 c/deg). Estimated visual acuity based on the extrapolated high-frequency cut off was 18 c/deg in the younger birds and 7.8 c/deg in the older birds. These results are in agreement with psychophysical data and retinal age-related losses in visual acuity, photoreceptors and retinal ganglion cells. Since these findings are comparable to those reported for humans, the results suggest that pigeons may serve as a useful model for human visual aging.

KW - Age

KW - ERG

KW - Flash

KW - Pattern

KW - Pigeons

KW - Retina

KW - Tectal evoked potential

UR - http://www.scopus.com/inward/record.url?scp=0026061915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026061915&partnerID=8YFLogxK

U2 - 10.1016/0042-6989(91)90007-R

DO - 10.1016/0042-6989(91)90007-R

M3 - Article

C2 - 1843768

AN - SCOPUS:0026061915

VL - 31

SP - 661

EP - 668

JO - Vision Research

JF - Vision Research

SN - 0042-6989

IS - 4

ER -