Electrophysiology of the postreceptoral visual pathway in mice

Vittorio Porciatti, Tommaso Pizzorusso, Lamberto Maffei

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Pattern VEPs have been recorded locally from the binocular portion of the primary visual cortex of wild type- and different transgenic mice by means of microelectrodes. Local pattern VEPs have been used on the one hand to obtain information on basic cortical layout (topography, laminar analysis) and ocularity (relative contribution of the contralateral and ipsilateral eye), and on the other hand to evaluate several aspects of visual physiology that have a counterpart in visual behavior (visual acuity, contrast sensitivity, motion sensitivity, response latency). As compared to visual behavior, pattern VEPs offer the advantage that several aspects of vision can be evaluated in the same animals, including those with poor behavior due to motor- or cognitive deficits, even during the postnatal development. Pattern VEPs provide a means for characterizing the visual phenotype of mutant mice and for the evaluation of the effects induced by experimental manipulation.

Original languageEnglish (US)
Pages (from-to)69-82
Number of pages14
JournalDocumenta Ophthalmologica
Volume104
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • Bcl-2
  • BDNF
  • Mouse
  • PERG
  • VEP
  • Visual cortex

ASJC Scopus subject areas

  • Ophthalmology

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