Electrophysiological effects of alprenolol on depressed canine myocardium

P. A. Guse, M. S. Gaide, Robert J Myerburg, K. Epstein, H. Gelband, A. L. Bassett

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The electrophysiological effects of the β-adrenergic antagonist, alprenolol, were compared in normal and depressed canine myocardium. Both (+) and (±)-alprenolol (5 x 10 -6 and 10 -5 mol.litre -1) decreased action potential amplitude and V̇max in Purkinje fibres superfused with Tyrode's solution in tissue bath. These concentrations shortened action potential duration and effective refractory period of Purkinje fibres but prolonged those of ventricular muscle. Alprenolol more markedly decreased V(max) and sometimes prevented action potential propagation in Purkinje fibres overlying infarcted regions. Similar depressant actions were noted in Purkinje fibres depolarised by exposure to 9 mmol.litre -1 K +. Depolarised and diseased myocardium is more sensitive to alprenolol and the drug's membrane depressant actions may be significant in terminating arrhythmias in such tissue.

Original languageEnglish
Pages (from-to)654-660
Number of pages7
JournalCardiovascular Research
Volume14
Issue number11
StatePublished - Dec 1 1980

Fingerprint

Alprenolol
Purkinje Fibers
Myocardium
Canidae
Action Potential
Fiber
Action Potentials
Fibers
Tissue
Arrhythmia
Adrenergic Antagonists
Baths
Muscle
Refractory materials
Cardiac Arrhythmias
Drugs
Membrane
Propagation
Membranes
Muscles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Cite this

Guse, P. A., Gaide, M. S., Myerburg, R. J., Epstein, K., Gelband, H., & Bassett, A. L. (1980). Electrophysiological effects of alprenolol on depressed canine myocardium. Cardiovascular Research, 14(11), 654-660.

Electrophysiological effects of alprenolol on depressed canine myocardium. / Guse, P. A.; Gaide, M. S.; Myerburg, Robert J; Epstein, K.; Gelband, H.; Bassett, A. L.

In: Cardiovascular Research, Vol. 14, No. 11, 01.12.1980, p. 654-660.

Research output: Contribution to journalArticle

Guse, PA, Gaide, MS, Myerburg, RJ, Epstein, K, Gelband, H & Bassett, AL 1980, 'Electrophysiological effects of alprenolol on depressed canine myocardium', Cardiovascular Research, vol. 14, no. 11, pp. 654-660.
Guse PA, Gaide MS, Myerburg RJ, Epstein K, Gelband H, Bassett AL. Electrophysiological effects of alprenolol on depressed canine myocardium. Cardiovascular Research. 1980 Dec 1;14(11):654-660.
Guse, P. A. ; Gaide, M. S. ; Myerburg, Robert J ; Epstein, K. ; Gelband, H. ; Bassett, A. L. / Electrophysiological effects of alprenolol on depressed canine myocardium. In: Cardiovascular Research. 1980 ; Vol. 14, No. 11. pp. 654-660.
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