Electrophysiologic Effects of Verapamil on Cells Bordering Healed Myocardial Infarction in the Cat

Samuel S. Wong, Robert J. Myerburg, John S. Cameron, Kristina Epstein, Alan M. Ezrin, Patricia Kozlovskis, Arthur L. Bassett

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Verapamil (1 μg/ml) completely abolished a population of markedly depressed action potentials of cells (BZ-1) in border zones around healed infarcts. Even at higher concentrations, verapamil had no such inhibitory effect on other border zone cells (BZ-2), normal and central infarct zones cells. BZ-1 cells demonstrated a severely depressed V̇(max) (<20 V/sec), accompanied by partial depolarization, while BZ-2 cells were characterized by abbreviated duration. Verapamil only significantly depressed V̇(max) of BZ-1 cells. Action potential amplitude and action potential duration of 50% repolarization of all cells were abbreviated by verapamil. These results indicate slow inward currents may be involved in the genesis of action potentials in BZ-1 cells.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume171
Issue number3
DOIs
StatePublished - Dec 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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