Electrophysiologic effects of intravenous propranolol in the intact immature mammalian heart

M. L. Young, A. Fournier, A. Stolfi, A. S. Pickoff

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Using intracardiac electrogram recording and stimulation techniques, 13 neonatal puppies (3-15 days) and 9 adult dogs were studied following cumulative doses of intravenous propranolol. Although propranolol caused a dose-dependent increase in the sinus cycle length in both groups, the increase was significantly less in the neonates than in the adults. In both groups the pacing interval resulting in atrioventricular (AV) nodal Wenckebach was increased significantly by propranolol; however, the increase was again less in the neonates than in the adults. There were comparable dose-dependent increases in atrial and ventricular refractoriness in both neonate and adult groups.

Original languageEnglish
Pages (from-to)125-134
Number of pages10
JournalDevelopmental Pharmacology and Therapeutics
Volume11
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes

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Propranolol
Cardiac Electrophysiologic Techniques
Dogs

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Electrophysiologic effects of intravenous propranolol in the intact immature mammalian heart. / Young, M. L.; Fournier, A.; Stolfi, A.; Pickoff, A. S.

In: Developmental Pharmacology and Therapeutics, Vol. 11, No. 3, 01.01.1988, p. 125-134.

Research output: Contribution to journalArticle

Young, M. L. ; Fournier, A. ; Stolfi, A. ; Pickoff, A. S. / Electrophysiologic effects of intravenous propranolol in the intact immature mammalian heart. In: Developmental Pharmacology and Therapeutics. 1988 ; Vol. 11, No. 3. pp. 125-134.
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