Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart

A. Fournier; M. L. Young; A. Stolfi; H. Gelband; A. S. Pickoff

doi:10.1159/000457704

Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart

A. Fournier, M. L. Young, A. Stolfi, H. Gelband, A. S. Pickoff

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.

Original language	English (US)
Pages (from-to)	288-296
Number of pages	9
Journal	Developmental Pharmacology and Therapeutics
Volume	11
Issue number	5
DOIs	https://doi.org/10.1159/000457704
State	Published - Jan 1 1988

Fingerprint

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

Cite this

Fournier, A., Young, M. L., Stolfi, A., Gelband, H., & Pickoff, A. S. (1988). Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart. Developmental Pharmacology and Therapeutics, 11(5), 288-296. https://doi.org/10.1159/000457704

@article{42da5dadd5c440c6ac9b276184801e83,

title = "Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart",

abstract = "The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.",

author = "A. Fournier and Young, {M. L.} and A. Stolfi and H. Gelband and Pickoff, {A. S.}",

year = "1988",

month = jan

day = "1",

doi = "10.1159/000457704",

language = "English (US)",

volume = "11",

pages = "288--296",

journal = "Developmental Pharmacology and Therapeutics",

issn = "0379-8305",

publisher = "S. Karger AG",

number = "5",

}

TY - JOUR

T1 - Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart

AU - Fournier, A.

AU - Young, M. L.

AU - Stolfi, A.

AU - Gelband, H.

AU - Pickoff, A. S.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.

AB - The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.

UR - http://www.scopus.com/inward/record.url?scp=0023705471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023705471&partnerID=8YFLogxK

U2 - 10.1159/000457704

DO - 10.1159/000457704

M3 - Article

C2 - 3191821

AN - SCOPUS:0023705471

VL - 11

SP - 288

EP - 296

JO - Developmental Pharmacology and Therapeutics

JF - Developmental Pharmacology and Therapeutics

SN - 0379-8305

IS - 5

ER -

Access to Document

10.1159/000457704