Abstract
The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.
| Original language | English |
|---|---|
| Pages (from-to) | 288-296 |
| Number of pages | 9 |
| Journal | Developmental Pharmacology and Therapeutics |
| Volume | 11 |
| Issue number | 5 |
| State | Published - Jan 1 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart. / Fournier, A.; Young, M. L.; Stolfi, A.; Gelband, H.; Pickoff, A. S.
In: Developmental Pharmacology and Therapeutics, Vol. 11, No. 5, 01.01.1988, p. 288-296.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart
AU - Fournier, A.
AU - Young, M. L.
AU - Stolfi, A.
AU - Gelband, H.
AU - Pickoff, A. S.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.
AB - The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023705471&partnerID=8YFLogxK
M3 - Article
VL - 11
SP - 288
EP - 296
JO - Developmental Pharmacology and Therapeutics
JF - Developmental Pharmacology and Therapeutics
SN - 0379-8305
IS - 5
ER -