Electrophysiologic and hemodynamic effects of bethanidine sulfate on the immature mammalian heart

A. Fournier, M. L. Young, A. Stolfi, H. Gelband, A. S. Pickoff

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Abstract

The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.

Original languageEnglish (US)
Pages (from-to)288-296
Number of pages9
JournalDevelopmental Pharmacology and Therapeutics
Volume11
Issue number5
DOIs
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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