Electronic effects on the selectivity of mercuracarborand ionophores in ion-selective electrodes and membrane formulations for their use in high protein concentration environments

R. Daniel Johnson, Ibrahim H.A. Badr, Martin Diaz, Timothy J. Wedge, M. Frederick Hawthorne, Leonidas G. Bachas

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Ion-selective electrodes based on the ionophore [9]mercuracarborand-3 (MC3) have been demonstrated in the past to be highly selective for the chloride ion. This ionophore is macrocyclic and possesses Lewis acidic mercury centers, both of which result in enhanced ionophore binding to spherical anions. Like their charge-reverse analogs, crown ethers, mercuracarborands offer the possibility to tune binding selectivity through changes in cavity size and/or via the incorporation of functional groups onto the cavity framework. Indeed, this article outlines the effect on ionophore selectivity that results from the addition of methyl groups to the MC3's carborane cages. Our results indicate that this simple functionalization leads to significant changes in selectivity that can be attributed to electronic effects. Furthermore, since MC3-based electrodes and optodes have previously shown sufficient selectivities to perform physiological analysis, the effect of protein backgrounds and mild exposure to human whole blood on the response of mercuracarborand ISEs is also reported.

Original languageEnglish (US)
Pages (from-to)1244-1250
Number of pages7
JournalElectroanalysis
Volume15
Issue number15-16
StatePublished - Sep 1 2003
Externally publishedYes

Keywords

  • Chloride
  • ISE-protein interactions
  • Ion-selective electrodes
  • Mercuracarborands

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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