Electron microscopic evidence of non-A, non-B hepatitis markers and virus-like particles in immunocompromised humans

S. Watanabe, K. R. Reddy, Lennox J Jeffers, Gordon Dickinson, M. O'Connell, Eugene R Schiff

Research output: Contribution to journalArticle

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Abstract

Characteristic pathological alterations of the liver in chimpanzees inoculated with non-A, non-B hepatitis sera have been described, but no corresponding findings have been reported in humans. Electron microscopic studies of the liver biopsy specimens of two homosexual patients with acquired immune deficiency syndrome, one without hepatitis (Patient 1) and one with chronic active hepatitis in remission (Patient 2), revealed the cytoplasmic tubular structures which are characteristic of chimpanzee non-A, non-B hepatitis. A cluster of 23 nm double-shelled particles was also seen in the cytoplasm of a hepatocyte in patient 1 who had received a blood transfusion 8 days before the biopsy. These particles were smaller than the Dane particles, Epstein-Barr virus, cytomegalovirus or herpes simplex virus, and different from hepatitis A virus particles; the antibodies to all of which are found in high concentration in acquired immune deficiency syndrome patients. These observations may reflect the morphologic findings for non-A, non-B hepatitis infection in humans.

Original languageEnglish
Pages (from-to)628-632
Number of pages5
JournalHepatology
Volume4
Issue number4
StatePublished - Sep 27 1984

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Hepatitis Viruses
Virion
Hepatitis
Electrons
Pan troglodytes
Acquired Immunodeficiency Syndrome
Cytoplasmic Structures
Biopsy
Hepatitis A virus
Liver
Simplexvirus
Chronic Hepatitis
Cytomegalovirus
Human Herpesvirus 4
Hepatitis B virus
Blood Transfusion
Hepatocytes
Cytoplasm
Antibodies
Infection

ASJC Scopus subject areas

  • Hepatology

Cite this

Electron microscopic evidence of non-A, non-B hepatitis markers and virus-like particles in immunocompromised humans. / Watanabe, S.; Reddy, K. R.; Jeffers, Lennox J; Dickinson, Gordon; O'Connell, M.; Schiff, Eugene R.

In: Hepatology, Vol. 4, No. 4, 27.09.1984, p. 628-632.

Research output: Contribution to journalArticle

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AB - Characteristic pathological alterations of the liver in chimpanzees inoculated with non-A, non-B hepatitis sera have been described, but no corresponding findings have been reported in humans. Electron microscopic studies of the liver biopsy specimens of two homosexual patients with acquired immune deficiency syndrome, one without hepatitis (Patient 1) and one with chronic active hepatitis in remission (Patient 2), revealed the cytoplasmic tubular structures which are characteristic of chimpanzee non-A, non-B hepatitis. A cluster of 23 nm double-shelled particles was also seen in the cytoplasm of a hepatocyte in patient 1 who had received a blood transfusion 8 days before the biopsy. These particles were smaller than the Dane particles, Epstein-Barr virus, cytomegalovirus or herpes simplex virus, and different from hepatitis A virus particles; the antibodies to all of which are found in high concentration in acquired immune deficiency syndrome patients. These observations may reflect the morphologic findings for non-A, non-B hepatitis infection in humans.

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