Electroencephalographic effects of intracerebroventricularly administered opioids: Effects of lithium

M. Simonato, O. C. Snead, R. S. Jope

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The EEG effects of opioids injected icv were studied in rats implanted with electrodes in the cortex, caudata, amygdala and hippocampus. All of the compounds tested (β-endorphin, leu-enkephalin, dynorphin, morphine, morphiceptin, DALE, DSLET) induced spikes and electrical seizures. The potency of the preferential δ agonist DSLET was two orders of magnitude greater than that of the preferential μ agonist morphiceptin. The profile of action of dynorphin was more complex than other opiates, as it included diazepam EEG desynchronization in some cases, electrical seizures and, eventually, behavioral convulsions in others. A specific μ antagonist, β-FNA, blocked the EEG effect of all the opioids except morphine. Lithium pretreatment potentiated the induction of seizures by morphicetin but not by other agonists. The results suggest an involvement of the μ receptors in opioid-induced electrical seizure activity, and confirm that δ receptors may play a role as well.

Original languageEnglish (US)
Pages (from-to)207-223
Number of pages17
JournalResearch Communications in Psychology, Psychiatry and Behavior
Volume14
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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