Electrocardiography and 24-hour electrocardiographic ambulatory recording (Holter monitor) studies in children infected with human immunodeficiency virus type 1

A. S. Saidi, D. S. Moodie, A. Garson, S. E. Lipshultz, S. Kaplan, W. W. Lai, S. D. Colan, T. J. Starc, S. Shanbhag, K. A. Easley, J. T. Bricker

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Limited data are available on the electrocardiogram and ambulatory electrocardiogram recording (Holter) in children infected with the human immunodeficiency virus type 1 (HIV-1). The purpose of this study was to estimate the prevalence and cumulative incidence of rhythm and conduction abnormalities in HIV-1-infected children. Electrocardiograms and Holter monitoring studies were performed annually on 205 HIV-1-infected children enrolled after 28 days of life (group I), 93 HIV-1-infected infants enrolled during pregnancy or during the first 28 days of life (group IIa), and 463 HIV-1-uninfected infants enrolled during pregnancy or during the first 28 days of life (group Ilb). The 5-year cumulative incidence in the group I children of second-degree atrioventricular block or supraventricular or ventricular tachycardia was 13.4%, and the 5-year incidence was higher for the older infected group I children (16,8% for children ≥4 years old at first study and 11,4% for children <4 years, p = 0.04). The mean corrected QT interval was also longer for the older infected group I children (p = 0.002) and prolonged in the HIV-1-infected compared to the HIV-1-uninfected group II children (p = 0.02). None of the children had atrial fibrillation or flutter. Arrhythmias are uncommon in children infected with HIV-1 and in children of HIV-1-infected mothers and the arrhythmias identified tend to be benign. Therefore, routine Holter monitoring does not appear to be indicated in asymptomatic children.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalPediatric Cardiology
Volume21
Issue number3
DOIs
StatePublished - May 1 2000

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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    Saidi, A. S., Moodie, D. S., Garson, A., Lipshultz, S. E., Kaplan, S., Lai, W. W., Colan, S. D., Starc, T. J., Shanbhag, S., Easley, K. A., & Bricker, J. T. (2000). Electrocardiography and 24-hour electrocardiographic ambulatory recording (Holter monitor) studies in children infected with human immunodeficiency virus type 1. Pediatric Cardiology, 21(3), 189-196. https://doi.org/10.1007/s002460010038