Electrocardiography and 24-hour electrocardiographic ambulatory recording (Holter monitor) studies in children infected with human immunodeficiency virus type 1

A. S. Saidi, D. S. Moodie, A. Garson, Steven E Lipshultz, S. Kaplan, W. W. Lai, S. D. Colan, T. J. Starc, S. Shanbhag, K. A. Easley, J. T. Bricker

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16 Scopus citations

Abstract

Limited data are available on the electrocardiogram and ambulatory electrocardiogram recording (Holter) in children infected with the human immunodeficiency virus type 1 (HIV-1). The purpose of this study was to estimate the prevalence and cumulative incidence of rhythm and conduction abnormalities in HIV-1-infected children. Electrocardiograms and Holter monitoring studies were performed annually on 205 HIV-1-infected children enrolled after 28 days of life (group I), 93 HIV-1-infected infants enrolled during pregnancy or during the first 28 days of life (group IIa), and 463 HIV-1-uninfected infants enrolled during pregnancy or during the first 28 days of life (group Ilb). The 5-year cumulative incidence in the group I children of second-degree atrioventricular block or supraventricular or ventricular tachycardia was 13.4%, and the 5-year incidence was higher for the older infected group I children (16,8% for children ≥4 years old at first study and 11,4% for children <4 years, p = 0.04). The mean corrected QT interval was also longer for the older infected group I children (p = 0.002) and prolonged in the HIV-1-infected compared to the HIV-1-uninfected group II children (p = 0.02). None of the children had atrial fibrillation or flutter. Arrhythmias are uncommon in children infected with HIV-1 and in children of HIV-1-infected mothers and the arrhythmias identified tend to be benign. Therefore, routine Holter monitoring does not appear to be indicated in asymptomatic children.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalPediatric Cardiology
Volume21
Issue number3
DOIs
StatePublished - May 1 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Saidi, A. S., Moodie, D. S., Garson, A., Lipshultz, S. E., Kaplan, S., Lai, W. W., Colan, S. D., Starc, T. J., Shanbhag, S., Easley, K. A., & Bricker, J. T. (2000). Electrocardiography and 24-hour electrocardiographic ambulatory recording (Holter monitor) studies in children infected with human immunodeficiency virus type 1. Pediatric Cardiology, 21(3), 189-196. https://doi.org/10.1007/s002460010038