Electroacupuncture potentiates the antinociceptive effect of intrathecal endomorphin-1 in the rat formalin test

Shuanglin Hao, Osamu Takahata, Hiroshi Iwasaki

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Endomorphin-1 is a novel endogenous mu-opioid peptide. In this study, we examined the effects of 2 Hz electroacupuncture in the rat tail flick test and the formalin test (a persistent noxious model). Moreover, we investigated if the electroacupuncture potentiated the effect of intrathecal endomorphin- 1. The results demonstrated that electroacupuncture alone produced a significant antinociception in the tail flick test, but not in the formalin test, and that intrathecal endomorphin-1 dose-dependently suppressed the biphasic nociceptive behavior in the formalin test. Electroacupuncture enhanced the antinociceptive effect of intrathecal endomorphin-1 in the formalin test, resulting in a significant leftward shift in the dose-response curves for intrathecal endomorphin-1 antinociception. The enhanced effect was antagonized by intraperitoneal naltrexone. The study suggests that electroacupuncture may potentiate the intrathecal endomorphin-1 antinociception partially mediated by opioid receptors. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalNeuroscience Letters
Volume287
Issue number1
DOIs
StatePublished - Jun 16 2000
Externally publishedYes

Keywords

  • Electroacupuncture
  • Endomorphin-1
  • Formalin test
  • Potentiation

ASJC Scopus subject areas

  • Neuroscience(all)

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