Electrical potentials associated with passive ion transport across chondrocyte membranes

Weiyong Gu, W. Michael Lai, Van C. Mow

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Previous studies on cartilage metabolism have focused on how mechanical signals are transmitted from the extracellular matrix into the cell to influence its synthesis activities as well as on mRNA expression. Mechanical loading on cartilage causes interstitial fluid flow, solid matrix deformation, streaming potential and other electrochemical effects which in turn cause passive ion transport across the cell membranes. This study determines the mechano-electrochemical events associated with the passive ion transport and fluid flow across a chondrocyte membrane. The passive ion transport across the thin membrane is described using a one-dimensional model. Several equations which provide the quantitative relationships between mechanical signals and electrochemical signals across the membrane are presented.

Original languageEnglish
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Place of PublicationNew York, NY, United States
PublisherASME
Pages27-28
Number of pages2
Volume29
StatePublished - Jan 1 1995
Externally publishedYes
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period6/28/957/2/95

ASJC Scopus subject areas

  • Engineering(all)

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