Efficient visible light induced nuclease activity of a ternary mono-1,10-phenanthroline copper(II) complex containing 2-(methylthio)ethylsalicylaldimine

Shanta Dhar, Akhil R. Chakravarty

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Ternary Schiff base copper(II) complex [CuL(phen)](ClO4), where HL is 2-(methylthio)ethylsalicylaldimine and phen is 1,10-phenanthroline, has been prepared and structurally characterized by X-ray crystallography. The complex shows a CuN3OS coordination in a square-pyramidal (4 + 1) geometry with the sulfur as an equatorial ligand. The complex is an avid binder to double-stranded DNA in the minor groove and exhibits both photonuclease and chemical nuclease activity. When exposed to UV light of 312 nm (96 W) or visible light of 532 nm (125 W) under aerobic conditions, the complex causes significant cleavage of supercoiled pUC19 DNA in the absence of any externally added reducing agent or H2O2.

Original languageEnglish (US)
Pages (from-to)2483-2485
Number of pages3
JournalInorganic Chemistry
Volume42
Issue number8
DOIs
StatePublished - Apr 21 2003
Externally publishedYes

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nuclease
deoxyribonucleic acid
copper
Schiff Bases
X ray crystallography
DNA
Reducing Agents
Sulfur
Ultraviolet radiation
grooves
imines
crystallography
Binders
Copper
cleavage
sulfur
Ligands
ligands
Geometry
causes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Cite this

Efficient visible light induced nuclease activity of a ternary mono-1,10-phenanthroline copper(II) complex containing 2-(methylthio)ethylsalicylaldimine. / Dhar, Shanta; Chakravarty, Akhil R.

In: Inorganic Chemistry, Vol. 42, No. 8, 21.04.2003, p. 2483-2485.

Research output: Contribution to journalArticle

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