Abstract
Ternary Schiff base copper(II) complex [CuL(phen)](ClO4), where HL is 2-(methylthio)ethylsalicylaldimine and phen is 1,10-phenanthroline, has been prepared and structurally characterized by X-ray crystallography. The complex shows a CuN3OS coordination in a square-pyramidal (4 + 1) geometry with the sulfur as an equatorial ligand. The complex is an avid binder to double-stranded DNA in the minor groove and exhibits both photonuclease and chemical nuclease activity. When exposed to UV light of 312 nm (96 W) or visible light of 532 nm (125 W) under aerobic conditions, the complex causes significant cleavage of supercoiled pUC19 DNA in the absence of any externally added reducing agent or H2O2.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2483-2485 |
| Number of pages | 3 |
| Journal | Inorganic Chemistry |
| Volume | 42 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 21 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry
Cite this
Efficient visible light induced nuclease activity of a ternary mono-1,10-phenanthroline copper(II) complex containing 2-(methylthio)ethylsalicylaldimine. / Dhar, Shanta; Chakravarty, Akhil R.
In: Inorganic Chemistry, Vol. 42, No. 8, 21.04.2003, p. 2483-2485.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficient visible light induced nuclease activity of a ternary mono-1,10-phenanthroline copper(II) complex containing 2-(methylthio)ethylsalicylaldimine
AU - Dhar, Shanta
AU - Chakravarty, Akhil R.
PY - 2003/4/21
Y1 - 2003/4/21
N2 - Ternary Schiff base copper(II) complex [CuL(phen)](ClO4), where HL is 2-(methylthio)ethylsalicylaldimine and phen is 1,10-phenanthroline, has been prepared and structurally characterized by X-ray crystallography. The complex shows a CuN3OS coordination in a square-pyramidal (4 + 1) geometry with the sulfur as an equatorial ligand. The complex is an avid binder to double-stranded DNA in the minor groove and exhibits both photonuclease and chemical nuclease activity. When exposed to UV light of 312 nm (96 W) or visible light of 532 nm (125 W) under aerobic conditions, the complex causes significant cleavage of supercoiled pUC19 DNA in the absence of any externally added reducing agent or H2O2.
AB - Ternary Schiff base copper(II) complex [CuL(phen)](ClO4), where HL is 2-(methylthio)ethylsalicylaldimine and phen is 1,10-phenanthroline, has been prepared and structurally characterized by X-ray crystallography. The complex shows a CuN3OS coordination in a square-pyramidal (4 + 1) geometry with the sulfur as an equatorial ligand. The complex is an avid binder to double-stranded DNA in the minor groove and exhibits both photonuclease and chemical nuclease activity. When exposed to UV light of 312 nm (96 W) or visible light of 532 nm (125 W) under aerobic conditions, the complex causes significant cleavage of supercoiled pUC19 DNA in the absence of any externally added reducing agent or H2O2.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037460004&partnerID=8YFLogxK
U2 - 10.1021/ic026241k
DO - 10.1021/ic026241k
M3 - Article
C2 - 12691551
AN - SCOPUS:0037460004
VL - 42
SP - 2483
EP - 2485
JO - Inorganic Chemistry
JF - Inorganic Chemistry
SN - 0020-1669
IS - 8
ER -