Efficient synthesis of viral nucleic acids following monocyte infection by HIV-1

Nina Heinzinger, Lisa Baca-Regen, Mario Stevenson, Howard E. Gendelman

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The replication of human immunodeficiency virus type 1 in mononuclear phagocytes (blood monocytes, tissue macrophages,and dendritic cells) is an important feature of HIV-1 pathogenesis. Although most primary HIV-1 isolates are able to productively infect monocytes, some reports suggest that rates of viral DNA synthesis and virus replication are reduced in HIV-1-infected monocytes as compared to infected T cells. In this study we compare kinetics of viral DNA synthesis in CD4+ T cells and monocytes following HIV-1 infection. Our results indicate that reverse transcription of viral nucleic acids following infection of monocytes occurs at rates equal to or greater than that observed following infection of T cells. These studies reveal no postentry restrictions to HIV-1 replication following infection in monocytes. Moreover, the results support the notion that both monocytes and CD4+ T cells are equally permissive for virus replication in infected individuals.

Original languageEnglish (US)
Article number95800972
Pages (from-to)731-735
Number of pages5
JournalVirology
Volume206
Issue number1
DOIs
StatePublished - Jan 1 1995

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ASJC Scopus subject areas

  • Virology

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