Efficacy of perioperative thromboprophylactic agents in the maintenance of anastamotic patency and survival of rat microvascular free groin flaps

Prad Murthy, Michael V. Riesberg, Steve Hart, Andres Bustillo, Carlos S. Duque, Sheriff Said, Francisco J. Civantos

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

OBJECTIVES: We sought to determine the thromboprophylactic effects of low-molecular-weight heparin (LMWH) and pentoxifylline. DESIGN: Randomized blinded study. MATERIALS AND METHODS: Sixty Sprague-Dawley rats were assigned to 1 of 4 treatment groups: (1) control group (n = 15), (2) pentoxifylline group (n = 15), (3) LMWH group (n = 15), and (4) combined therapy group (n = 15). A groin/abdominal free flap was elevated in each, with division of the artery and microvascular repair The animals received therapy for 4 days preoperatively and 6 days postoperatively. Flaps were monitored visually, and on the seventh postoperative day, the flap was elevated, and the microvascular anastomosis was assessed for patency. RESULTS: There was a statistically significant improvement in arterial patency in both pentoxifylline and LMWH groups compared with controls (P < 0.01) but no significant improvement with combined therapy (P > 0.05). CONCLUSIONS: In this animal model, LMWH and pentoxifylline have significant thrombroprophylacfic effects when used individually but not in combination.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume129
Issue number3
DOIs
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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