Efficacy of N-acetyl cysteine in traumatic brain injury

Katharine Eakin, Renana Baratz-Goldstein, Chiam G. Pick, Ofra Zindel, Carey D. Balaban, Michael E Hoffer, Megan Lockwood, Jonathan Miller, Barry J. Hoffer

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In this study, using two different injury models in two different species, we found that early post-injury treatment with NAcetyl Cysteine (NAC) reversed the behavioral deficits associated with the TBI. These data suggest generalization of a protocol similar to our recent clinical trial with NAC in blast-induced mTBI in a battlefield setting [1], to mild concussion from blunt trauma. This study used both weight drop in mice and fluid percussion injury in rats. These were chosen to simulate either mild or moderate traumatic brain injury (TBI). For mice, we used novel object recognition and the Y maze. For rats, we used the Morris water maze. NAC was administered beginning 30-60 minutes after injury. Behavioral deficits due to injury in both species were significantly reversed by NAC treatment. We thus conclude NAC produces significant behavioral recovery after injury. Future preclinical studies are needed to define the mechanism of action, perhaps leading to more effective therapies in man.

Original languageEnglish (US)
Article numbere90617
JournalPLoS One
Volume9
Issue number4
DOIs
StatePublished - Apr 16 2014
Externally publishedYes

Fingerprint

Acetylcysteine
acetylcysteine
Cysteine
cysteine
Brain
brain
Wounds and Injuries
Rats
rats
mice
Object recognition
Brain Concussion
Percussion
clinical trials
mechanism of action
Traumatic Brain Injury
Recovery
therapeutics
Fluids
Water

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Eakin, K., Baratz-Goldstein, R., Pick, C. G., Zindel, O., Balaban, C. D., Hoffer, M. E., ... Hoffer, B. J. (2014). Efficacy of N-acetyl cysteine in traumatic brain injury. PLoS One, 9(4), [e90617]. https://doi.org/10.1371/journal.pone.0090617

Efficacy of N-acetyl cysteine in traumatic brain injury. / Eakin, Katharine; Baratz-Goldstein, Renana; Pick, Chiam G.; Zindel, Ofra; Balaban, Carey D.; Hoffer, Michael E; Lockwood, Megan; Miller, Jonathan; Hoffer, Barry J.

In: PLoS One, Vol. 9, No. 4, e90617, 16.04.2014.

Research output: Contribution to journalArticle

Eakin, K, Baratz-Goldstein, R, Pick, CG, Zindel, O, Balaban, CD, Hoffer, ME, Lockwood, M, Miller, J & Hoffer, BJ 2014, 'Efficacy of N-acetyl cysteine in traumatic brain injury', PLoS One, vol. 9, no. 4, e90617. https://doi.org/10.1371/journal.pone.0090617
Eakin K, Baratz-Goldstein R, Pick CG, Zindel O, Balaban CD, Hoffer ME et al. Efficacy of N-acetyl cysteine in traumatic brain injury. PLoS One. 2014 Apr 16;9(4). e90617. https://doi.org/10.1371/journal.pone.0090617
Eakin, Katharine ; Baratz-Goldstein, Renana ; Pick, Chiam G. ; Zindel, Ofra ; Balaban, Carey D. ; Hoffer, Michael E ; Lockwood, Megan ; Miller, Jonathan ; Hoffer, Barry J. / Efficacy of N-acetyl cysteine in traumatic brain injury. In: PLoS One. 2014 ; Vol. 9, No. 4.
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