Efficacy of intralesional immunotherapy for the treatment of warts: A review of the literature

Adam Souhail Aldahan, Stephanie Mlacker, Vidhi V. Shah, Preetha Kamath, Mohammed Alsaidan, Sahal Samarkandy, Keyvan Nouri

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Warts are common epidermal growths caused by human papillomavirus that often cause significant discomfort and embarrassment. Current treatment options include topical therapies, cryotherapy, laser vaporization, and surgical excision. Many of these options are destructive and may result in scarring, while less aggressive approaches can lead to lesion recurrence. Additionally, these local modalities are not practical for patients with a large number of warts. Systemic approaches such as immunotherapy have demonstrated success in treating multiple lesions by combining a targeted approach with upregulation of the host immune system. An extensive literature review was performed to evaluate the various vaccine antigens that have been used intralesionally to treat cutaneous and anogenital warts. The specific intralesional immunotherapies that have been studied include: Candida albicans; measles, mumps, and rubella; Trichophyton; and tuberculin antigens such as purified protein derivative, Mycobacterium w vaccine, and Bacillus Calmette-Guerin. Intralesional vaccine injection represents a safe, effective, and tolerable treatment for warts, including recalcitrant and anogenital warts. This approach has been somewhat overlooked in the past despite substantial evidence of high response rates with a low side effect profile. Large comparative trials are necessary to determine the most effective immunotherapy treatment option as well as the most appropriate dosing parameters.

Original languageEnglish (US)
Pages (from-to)197-207
Number of pages11
JournalDermatologic Therapy
Volume29
Issue number3
DOIs
StatePublished - May 1 2016

Fingerprint

Warts
Immunotherapy
Vaccines
Intralesional Injections
Therapeutics
Antigens
Mumps
Trichophyton
Cryotherapy
Rubella
Tuberculin
Measles
Laser Therapy
Mycobacterium bovis
Candida albicans
Cicatrix
Immune System
Up-Regulation
Recurrence
Skin

Keywords

  • immunotherapy
  • intralesional
  • vaccines
  • verruca
  • warts

ASJC Scopus subject areas

  • Dermatology

Cite this

Aldahan, A. S., Mlacker, S., Shah, V. V., Kamath, P., Alsaidan, M., Samarkandy, S., & Nouri, K. (2016). Efficacy of intralesional immunotherapy for the treatment of warts: A review of the literature. Dermatologic Therapy, 29(3), 197-207. https://doi.org/10.1111/dth.12352

Efficacy of intralesional immunotherapy for the treatment of warts : A review of the literature. / Aldahan, Adam Souhail; Mlacker, Stephanie; Shah, Vidhi V.; Kamath, Preetha; Alsaidan, Mohammed; Samarkandy, Sahal; Nouri, Keyvan.

In: Dermatologic Therapy, Vol. 29, No. 3, 01.05.2016, p. 197-207.

Research output: Contribution to journalReview article

Aldahan, AS, Mlacker, S, Shah, VV, Kamath, P, Alsaidan, M, Samarkandy, S & Nouri, K 2016, 'Efficacy of intralesional immunotherapy for the treatment of warts: A review of the literature', Dermatologic Therapy, vol. 29, no. 3, pp. 197-207. https://doi.org/10.1111/dth.12352
Aldahan AS, Mlacker S, Shah VV, Kamath P, Alsaidan M, Samarkandy S et al. Efficacy of intralesional immunotherapy for the treatment of warts: A review of the literature. Dermatologic Therapy. 2016 May 1;29(3):197-207. https://doi.org/10.1111/dth.12352
Aldahan, Adam Souhail ; Mlacker, Stephanie ; Shah, Vidhi V. ; Kamath, Preetha ; Alsaidan, Mohammed ; Samarkandy, Sahal ; Nouri, Keyvan. / Efficacy of intralesional immunotherapy for the treatment of warts : A review of the literature. In: Dermatologic Therapy. 2016 ; Vol. 29, No. 3. pp. 197-207.
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