Efficacy of infection control interventions in reducing the spread of multidrug-resistant organisms in the hospital setting

Erika M C D'Agata, Mary Ann Horn, Shigui Ruan, Glenn F. Webb, Joanna R. Wares

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Multidrug-resistant organisms (MDRO) continue to spread in hospitals globally, but the population-level impact of recommended preventive strategies and the relative benefit of individual strategies targeting all MDRO in the hospital setting are unclear. To explore the dynamics of MDRO transmission in the hospital, we develop a model extending data from clinical individual-level studies to quantify the impact of hand hygiene, contact precautions, reducing antimicrobial exposure and screening surveillance cultures in decreasing the prevalence of MDRO colonization and infection. The effect of an ongoing increase in the influx of patients colonized with MDRO into the hospital setting is also quantified. We find that most recommended strategies have substantial effect in decreasing the prevalence of MDRO over time. However, screening for asymptomatic MDRO colonization among patients who are not receiving antimicrobials is of minimal value in reducing the spread of MDRO.

Original languageEnglish (US)
Article numbere30170
JournalPLoS One
Volume7
Issue number2
DOIs
StatePublished - Feb 20 2012

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Infection Control
disease control
organisms
Screening
Hand Hygiene
anti-infective agents
screening
Infection
hygiene
Population
hands
monitoring
infection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Efficacy of infection control interventions in reducing the spread of multidrug-resistant organisms in the hospital setting. / D'Agata, Erika M C; Horn, Mary Ann; Ruan, Shigui; Webb, Glenn F.; Wares, Joanna R.

In: PLoS One, Vol. 7, No. 2, e30170, 20.02.2012.

Research output: Contribution to journalArticle

D'Agata, Erika M C ; Horn, Mary Ann ; Ruan, Shigui ; Webb, Glenn F. ; Wares, Joanna R. / Efficacy of infection control interventions in reducing the spread of multidrug-resistant organisms in the hospital setting. In: PLoS One. 2012 ; Vol. 7, No. 2.
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