TY - JOUR
T1 - Efficacy of Hetastarch in the Resuscitation of Patients With Multisystem Trauma and Shock
AU - Shatney, Clayton H.
AU - Deepika, Krishnapradad
AU - Militello, Phillip R.
AU - Majerus, Thomas C.
AU - Dawson, R. Ben
PY - 1983/7
Y1 - 1983/7
N2 - A prospective trial of 6% hetastarch (HES) v 5% plasma protein fraction (PPF) as the colloid component of intravenous (IV) fluid resuscitation was conducted in 32 patients with multisystem trauma and/or hemorrhagic shock. Patient age, mechanism and pattern of injury, and IV fluid requirements were similar in both groups. No intergroup differences were noted in indexes of hepatic, pulmonary, or renal function or in the incidence of infection. The frequency of other complications, including bleeding diatheses, and mortality were identical in the two groups. Although this investigation should be viewed as a pilot study, our results suggest that, compared with PPF, HES in large volumes is a safe, effective colloid solution in the resuscitation of patients with multisystem trauma and/or hemorrhagic shock. Further study of HES in a larger number of patients is warranted by these findings.
AB - A prospective trial of 6% hetastarch (HES) v 5% plasma protein fraction (PPF) as the colloid component of intravenous (IV) fluid resuscitation was conducted in 32 patients with multisystem trauma and/or hemorrhagic shock. Patient age, mechanism and pattern of injury, and IV fluid requirements were similar in both groups. No intergroup differences were noted in indexes of hepatic, pulmonary, or renal function or in the incidence of infection. The frequency of other complications, including bleeding diatheses, and mortality were identical in the two groups. Although this investigation should be viewed as a pilot study, our results suggest that, compared with PPF, HES in large volumes is a safe, effective colloid solution in the resuscitation of patients with multisystem trauma and/or hemorrhagic shock. Further study of HES in a larger number of patients is warranted by these findings.
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U2 - 10.1001/archsurg.1983.01390070016004
DO - 10.1001/archsurg.1983.01390070016004
M3 - Article
C2 - 6190466
AN - SCOPUS:0020574249
VL - 118
SP - 804
EP - 809
JO - JAMA Surgery
JF - JAMA Surgery
SN - 2168-6254
IS - 7
ER -