Efficacy of Hetastarch in the Resuscitation of Patients With Multisystem Trauma and Shock

Clayton H. Shatney, Krishnapradad Deepika, Phillip R. Militello, Thomas C. Majerus, R. Ben Dawson

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

A prospective trial of 6% hetastarch (HES) v 5% plasma protein fraction (PPF) as the colloid component of intravenous (IV) fluid resuscitation was conducted in 32 patients with multisystem trauma and/or hemorrhagic shock. Patient age, mechanism and pattern of injury, and IV fluid requirements were similar in both groups. No intergroup differences were noted in indexes of hepatic, pulmonary, or renal function or in the incidence of infection. The frequency of other complications, including bleeding diatheses, and mortality were identical in the two groups. Although this investigation should be viewed as a pilot study, our results suggest that, compared with PPF, HES in large volumes is a safe, effective colloid solution in the resuscitation of patients with multisystem trauma and/or hemorrhagic shock. Further study of HES in a larger number of patients is warranted by these findings.

Original languageEnglish (US)
Pages (from-to)804-809
Number of pages6
JournalArchives of Surgery
Volume118
Issue number7
DOIs
StatePublished - Jul 1983

ASJC Scopus subject areas

  • Surgery

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    Shatney, C. H., Deepika, K., Militello, P. R., Majerus, T. C., & Dawson, R. B. (1983). Efficacy of Hetastarch in the Resuscitation of Patients With Multisystem Trauma and Shock. Archives of Surgery, 118(7), 804-809. https://doi.org/10.1001/archsurg.1983.01390070016004