Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Maria Del Pilar Hernandez, Mohammad D. Mansouri, Saima Aslam, Barry Zeluff, Rabih O. Darouiche

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Original languageEnglish (US)
Pages (from-to)190-192
Number of pages3
JournalInfection Control and Hospital Epidemiology
Volume30
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

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Heart-Assist Devices
Acetylcysteine
Amphotericin B
Staphylococcus aureus
Rabbits
Equipment and Supplies
gentamicin B
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology (medical)
  • Epidemiology
  • Infectious Diseases

Cite this

Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices. / Del Pilar Hernandez, Maria; Mansouri, Mohammad D.; Aslam, Saima; Zeluff, Barry; Darouiche, Rabih O.

In: Infection Control and Hospital Epidemiology, Vol. 30, No. 2, 02.2009, p. 190-192.

Research output: Contribution to journalArticle

Del Pilar Hernandez, Maria ; Mansouri, Mohammad D. ; Aslam, Saima ; Zeluff, Barry ; Darouiche, Rabih O. / Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices. In: Infection Control and Hospital Epidemiology. 2009 ; Vol. 30, No. 2. pp. 190-192.
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