Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Maria D. Hernandez; Mohammad D. Mansouri; Saima Aslam; Barry Zeluff; Rabih O. Darouiche

doi:10.1086/593205

Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Maria D. Hernandez, Mohammad D. Mansouri, Saima Aslam, Barry Zeluff, Rabih O. Darouiche

Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Original language	English (US)
Pages (from-to)	190-192
Number of pages	3
Journal	Infection control and hospital epidemiology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1086/593205
State	Published - Feb 1 2009

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1086/593205

Fingerprint Dive into the research topics of 'Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices'. Together they form a unique fingerprint.

Cite this

Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices. / Hernandez, Maria D.; Mansouri, Mohammad D.; Aslam, Saima; Zeluff, Barry; Darouiche, Rabih O.

In: Infection control and hospital epidemiology, Vol. 30, No. 2, 01.02.2009, p. 190-192.

Research output: Contribution to journal › Article › peer-review

@article{d96de024cdec4d0591ccc10c7685cb8d,

title = "Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices",

abstract = "We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.",

author = "Hernandez, {Maria D.} and Mansouri, {Mohammad D.} and Saima Aslam and Barry Zeluff and Darouiche, {Rabih O.}",

year = "2009",

month = feb,

day = "1",

doi = "10.1086/593205",

language = "English (US)",

volume = "30",

pages = "190--192",

journal = "Infection Control and Hospital Epidemiology",

issn = "0899-823X",

publisher = "University of Chicago Press",

number = "2",

}

TY - JOUR

T1 - Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

AU - Hernandez, Maria D.

AU - Mansouri, Mohammad D.

AU - Aslam, Saima

AU - Zeluff, Barry

AU - Darouiche, Rabih O.

PY - 2009/2/1

Y1 - 2009/2/1

N2 - We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

AB - We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

UR - http://www.scopus.com/inward/record.url?scp=58849124172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849124172&partnerID=8YFLogxK

U2 - 10.1086/593205

DO - 10.1086/593205

M3 - Article

C2 - 19090771

AN - SCOPUS:58849124172

VL - 30

SP - 190

EP - 192

JO - Infection Control and Hospital Epidemiology

JF - Infection Control and Hospital Epidemiology

SN - 0899-823X

IS - 2

ER -

Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this