Abstract
We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 190-192 |
| Number of pages | 3 |
| Journal | Infection Control and Hospital Epidemiology |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology (medical)
- Epidemiology
- Infectious Diseases
Cite this
Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices. / Del Pilar Hernandez, Maria; Mansouri, Mohammad D.; Aslam, Saima; Zeluff, Barry; Darouiche, Rabih O.
In: Infection Control and Hospital Epidemiology, Vol. 30, No. 2, 02.2009, p. 190-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices
AU - Del Pilar Hernandez, Maria
AU - Mansouri, Mohammad D.
AU - Aslam, Saima
AU - Zeluff, Barry
AU - Darouiche, Rabih O.
PY - 2009/2
Y1 - 2009/2
N2 - We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.
AB - We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.
UR - http://www.scopus.com/inward/record.url?scp=58849124172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58849124172&partnerID=8YFLogxK
U2 - 10.1086/593205
DO - 10.1086/593205
M3 - Article
C2 - 19090771
AN - SCOPUS:58849124172
VL - 30
SP - 190
EP - 192
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
SN - 0899-823X
IS - 2
ER -