Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Maria D. Hernandez; Mohammad D. Mansouri; Saima Aslam; Barry Zeluff; Rabih O. Darouiche

doi:10.1086/593205

Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Maria D. Hernandez, Mohammad D. Mansouri, Saima Aslam, Barry Zeluff, Rabih O. Darouiche

Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Original language	English (US)
Pages (from-to)	190-192
Number of pages	3
Journal	Infection control and hospital epidemiology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1086/593205
State	Published - Feb 1 2009

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices. / Hernandez, Maria D.; Mansouri, Mohammad D.; Aslam, Saima; Zeluff, Barry; Darouiche, Rabih O.

In: Infection control and hospital epidemiology, Vol. 30, No. 2, 01.02.2009, p. 190-192.

Research output: Contribution to journal › Article › peer-review

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