Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices

Maria D. Hernandez, Mohammad D. Mansouri, Saima Aslam, Barry Zeluff, Rabih O. Darouiche

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Original languageEnglish (US)
Pages (from-to)190-192
Number of pages3
JournalInfection control and hospital epidemiology
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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