Efficacy of azithromycin as a causal prophylactic agent against murine malaria

S. L. Andersen, A. L. Ager, P. McGreevy, B. G. Schuster, W. Ellis, J. Berman

Research output: Contribution to journalComment/debate

30 Scopus citations

Abstract

The efficacy of the newly marketed azalide azithromycin was compared with that of the clinical agent doxycycline in a murine model of sporozoite- induced malaria. Drug was administered once; Plasmodium yoelii sporozoites were administered 2 h later; survival at day 60 was determined. For parenterally administered drug, 160 mg of azithromycin or doxycycline per kg of body weight was 100% effective; 40 mg of azithromycin per kg was 80% effective, but 40 mg of doxycycline per kg was 40% effective. Orally administered azithromycin was somewhat less effective than parenterally administered drug, consistent with the 37% clinical oral bioavailability of this agent. For orally administered azithromycin, 160 mg/kg was 100% effective and 40 mg/kg was 40% effective. The efficacy of azithromycin in comparison with that of doxycycline and the known prolonged levels of azithromycin in the livers of humans suggest that azithromycin has potential as a clinical causal prophylactic agent for malaria.

Original languageEnglish (US)
Pages (from-to)1862-1863
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume38
Issue number8
DOIs
StatePublished - Jan 1 1994

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Andersen, S. L., Ager, A. L., McGreevy, P., Schuster, B. G., Ellis, W., & Berman, J. (1994). Efficacy of azithromycin as a causal prophylactic agent against murine malaria. Antimicrobial agents and chemotherapy, 38(8), 1862-1863. https://doi.org/10.1128/AAC.38.8.1862