Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial

Diana D. Cardenas, Catherine A. Warms, Judith A. Turner, Helen Marshall, Marvin M. Brooke, John D. Loeser

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Chronic pain in persons with spinal cord injury (SCI) is a difficult problem for which there is no simple method of treatment. Few randomized controlled trials of medications for pain in persons with SCI have been conducted. This study was designed to determine whether amitriptyline, a tricyclic antidepressant, is efficacious in relieving chronic pain and improving pain-related physical and psychosocial dysfunction in persons with SCI. Eighty-four participants with SCI and chronic pain were randomized to a 6-week trial of amitriptyline or an active placebo, benztropine mesylate. All pre- and post-treatment assessments were conducted by evaluators blind to the allocation. Regression analyses were conducted to examine whether there was a medication group effect on the primary (average pain intensity) and secondary outcome measures. No significant differences were found between the groups in pain intensity or pain-related disability post-treatment, in either intent-to-treat analyses or analyses of study completers. These findings do not support the use of amitriptyline in the treatment of chronic pain in this population, but we cannot rule out the possibility that certain subgroups may benefit.

Original languageEnglish
Pages (from-to)365-373
Number of pages9
JournalPain
Volume96
Issue number3
DOIs
StatePublished - Apr 27 2002
Externally publishedYes

Fingerprint

Amitriptyline
Spinal Cord Injuries
Randomized Controlled Trials
Chronic Pain
Pain
Benztropine
Therapeutics
Tricyclic Antidepressive Agents
Placebos
Regression Analysis
Outcome Assessment (Health Care)
Population

Keywords

  • Amitriptyline
  • Chronic pain
  • Spinal cord injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Cardenas, D. D., Warms, C. A., Turner, J. A., Marshall, H., Brooke, M. M., & Loeser, J. D. (2002). Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial. Pain, 96(3), 365-373. https://doi.org/10.1016/S0304-3959(01)00483-3

Efficacy of amitriptyline for relief of pain in spinal cord injury : Results of a randomized controlled trial. / Cardenas, Diana D.; Warms, Catherine A.; Turner, Judith A.; Marshall, Helen; Brooke, Marvin M.; Loeser, John D.

In: Pain, Vol. 96, No. 3, 27.04.2002, p. 365-373.

Research output: Contribution to journalArticle

Cardenas, DD, Warms, CA, Turner, JA, Marshall, H, Brooke, MM & Loeser, JD 2002, 'Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial', Pain, vol. 96, no. 3, pp. 365-373. https://doi.org/10.1016/S0304-3959(01)00483-3
Cardenas, Diana D. ; Warms, Catherine A. ; Turner, Judith A. ; Marshall, Helen ; Brooke, Marvin M. ; Loeser, John D. / Efficacy of amitriptyline for relief of pain in spinal cord injury : Results of a randomized controlled trial. In: Pain. 2002 ; Vol. 96, No. 3. pp. 365-373.
@article{324eda4a46004e77ae4862d3fe03e012,
title = "Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial",
abstract = "Chronic pain in persons with spinal cord injury (SCI) is a difficult problem for which there is no simple method of treatment. Few randomized controlled trials of medications for pain in persons with SCI have been conducted. This study was designed to determine whether amitriptyline, a tricyclic antidepressant, is efficacious in relieving chronic pain and improving pain-related physical and psychosocial dysfunction in persons with SCI. Eighty-four participants with SCI and chronic pain were randomized to a 6-week trial of amitriptyline or an active placebo, benztropine mesylate. All pre- and post-treatment assessments were conducted by evaluators blind to the allocation. Regression analyses were conducted to examine whether there was a medication group effect on the primary (average pain intensity) and secondary outcome measures. No significant differences were found between the groups in pain intensity or pain-related disability post-treatment, in either intent-to-treat analyses or analyses of study completers. These findings do not support the use of amitriptyline in the treatment of chronic pain in this population, but we cannot rule out the possibility that certain subgroups may benefit.",
keywords = "Amitriptyline, Chronic pain, Spinal cord injury",
author = "Cardenas, {Diana D.} and Warms, {Catherine A.} and Turner, {Judith A.} and Helen Marshall and Brooke, {Marvin M.} and Loeser, {John D.}",
year = "2002",
month = "4",
day = "27",
doi = "10.1016/S0304-3959(01)00483-3",
language = "English",
volume = "96",
pages = "365--373",
journal = "Pain",
issn = "0304-3959",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Efficacy of amitriptyline for relief of pain in spinal cord injury

T2 - Results of a randomized controlled trial

AU - Cardenas, Diana D.

AU - Warms, Catherine A.

AU - Turner, Judith A.

AU - Marshall, Helen

AU - Brooke, Marvin M.

AU - Loeser, John D.

PY - 2002/4/27

Y1 - 2002/4/27

N2 - Chronic pain in persons with spinal cord injury (SCI) is a difficult problem for which there is no simple method of treatment. Few randomized controlled trials of medications for pain in persons with SCI have been conducted. This study was designed to determine whether amitriptyline, a tricyclic antidepressant, is efficacious in relieving chronic pain and improving pain-related physical and psychosocial dysfunction in persons with SCI. Eighty-four participants with SCI and chronic pain were randomized to a 6-week trial of amitriptyline or an active placebo, benztropine mesylate. All pre- and post-treatment assessments were conducted by evaluators blind to the allocation. Regression analyses were conducted to examine whether there was a medication group effect on the primary (average pain intensity) and secondary outcome measures. No significant differences were found between the groups in pain intensity or pain-related disability post-treatment, in either intent-to-treat analyses or analyses of study completers. These findings do not support the use of amitriptyline in the treatment of chronic pain in this population, but we cannot rule out the possibility that certain subgroups may benefit.

AB - Chronic pain in persons with spinal cord injury (SCI) is a difficult problem for which there is no simple method of treatment. Few randomized controlled trials of medications for pain in persons with SCI have been conducted. This study was designed to determine whether amitriptyline, a tricyclic antidepressant, is efficacious in relieving chronic pain and improving pain-related physical and psychosocial dysfunction in persons with SCI. Eighty-four participants with SCI and chronic pain were randomized to a 6-week trial of amitriptyline or an active placebo, benztropine mesylate. All pre- and post-treatment assessments were conducted by evaluators blind to the allocation. Regression analyses were conducted to examine whether there was a medication group effect on the primary (average pain intensity) and secondary outcome measures. No significant differences were found between the groups in pain intensity or pain-related disability post-treatment, in either intent-to-treat analyses or analyses of study completers. These findings do not support the use of amitriptyline in the treatment of chronic pain in this population, but we cannot rule out the possibility that certain subgroups may benefit.

KW - Amitriptyline

KW - Chronic pain

KW - Spinal cord injury

UR - http://www.scopus.com/inward/record.url?scp=0036222008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036222008&partnerID=8YFLogxK

U2 - 10.1016/S0304-3959(01)00483-3

DO - 10.1016/S0304-3959(01)00483-3

M3 - Article

C2 - 11973011

AN - SCOPUS:0036222008

VL - 96

SP - 365

EP - 373

JO - Pain

JF - Pain

SN - 0304-3959

IS - 3

ER -