Efficacy of adhesion barriers: Resorbable hydrogel, oxidized regenerated cellulose and hyaluronic acid

Jennifer L. West, Sanghamitra M. Chowdhury, Amarpreet S. Sawhney, Chandrashekhar P. Pathak, Randall C. Dunn, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

OBJECTIVE: To compare a novel resorbable hydrogel barrier with two previously studied barriers, oxidized regenerated cellulose and hyaluronic acid, for the prevention of postoperative adhesions. STUDY DESIGN: Two models were employed in the rat uterine horn, one of adhesion formation after devascularization and serosal injury and one of adhesion reformation after adhesiolysis. RESULTS: In the devascularization model, hydrogel treatment reduced the mean extent of adhesion formation from 73% in the control group to 13% (P <.005). Hyaluronic acid pretreatment reduced the extent of adhesion formation to 44% (P < .05), while oxidized regenerated cellulose failed to reduce formation (P > .25). In the adhesiolysis model, treatment with the hydrogel reduced the mean extent of adhesion formation from 87% in the control group to 20% (P < .005). Neither the oxidized regenerated cellulose nor the hyaluronic acid treatments lowered the extent of adhesion formation from the control group (P > .25). The hydrogel barrier was observed to be resorbed over a five-day period and remained adherent to the tissue during resorption. CONCLUSION: Resorbable hydrogel barriers are highly effective in the reduction of adhesion formation and reformation in the rat. This is probably due to the good biocompatibility and retention of these materials upon the site of application.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume41
Issue number3
StatePublished - Mar 25 1996

Keywords

  • adhesions

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

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    West, J. L., Chowdhury, S. M., Sawhney, A. S., Pathak, C. P., Dunn, R. C., & Hubbell, J. A. (1996). Efficacy of adhesion barriers: Resorbable hydrogel, oxidized regenerated cellulose and hyaluronic acid. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 41(3), 149-154.