Efficacy of a bio-electric dressing in healing deep, partial-thickness wounds using a porcine model

Andrew C. Harding, Joel Gil Rodriguez, Jose Valdes, Michael Solis, Stephen C Davis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Numerous physical modalities have been used in attempts to augment the healing process, including ultrasound, low-energy light therapy, and electrical stimulation (ES). ES has been shown to benefit tissue repair in a variety of wound types, but variations in study designs, administration, and parameters render its application in clinical practice somewhat unconventional. A dressing was designed to generate an electric potential of 0.6 V to 0.7 V in the presence of moisture, thereby delivering a sustained micro-current without the need for an external power source. The purpose of this study was to examine the effects of this bio-electric dressing (BED) on deep, partial-thickness wounds using six female specific pathogen-free animals and a well established porcine model for wound healing. Wounds (10 mm × 7 mm × 0.5 mm) were created in paravertebral and thoracic areas of these animals using a specialized electrokeratome and covered with the active polyester BED and a polyurethane film dressing (n ≤ 30) (treatment) or an inactive polyester and film dressing (n ≤ 30). Using an epidermal migration assay, wounds were assessed daily from day 4 through day 8 post-wounding. Differ-ences in the proportion of wounds healed were statistically significant (P <0.001) on days 5 and 6 post-wounding. These results show BED is more effective than a control dressing treatment with moisture-retentive dressings in this animal model. Controlled clinical studies are warranted to elucidate the potential clinical implications of this treatment modality.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalOstomy Wound Management
Volume58
Issue number9
StatePublished - Sep 1 2012

Fingerprint

Bandages
Swine
Wounds and Injuries
Polyesters
Electric Stimulation
Electric Power Supplies
Specific Pathogen-Free Organisms
Phototherapy
Polyurethanes
Wound Healing
Thorax
Therapeutics
Animal Models

Keywords

  • animal experimentation
  • electric stimulation
  • epithelium
  • occlusive dressings
  • wound healing

ASJC Scopus subject areas

  • Gastroenterology
  • Internal Medicine
  • Nursing(all)

Cite this

Efficacy of a bio-electric dressing in healing deep, partial-thickness wounds using a porcine model. / Harding, Andrew C.; Gil Rodriguez, Joel; Valdes, Jose; Solis, Michael; Davis, Stephen C.

In: Ostomy Wound Management, Vol. 58, No. 9, 01.09.2012, p. 50-55.

Research output: Contribution to journalArticle

Harding, Andrew C. ; Gil Rodriguez, Joel ; Valdes, Jose ; Solis, Michael ; Davis, Stephen C. / Efficacy of a bio-electric dressing in healing deep, partial-thickness wounds using a porcine model. In: Ostomy Wound Management. 2012 ; Vol. 58, No. 9. pp. 50-55.
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