Efficacy of a bio-electric dressing in healing deep, partial-thickness wounds using a porcine model

Andrew C. Harding, Joel Gil, Jose Valdes, Michael Solis, Stephen C. Davis

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Numerous physical modalities have been used in attempts to augment the healing process, including ultrasound, low-energy light therapy, and electrical stimulation (ES). ES has been shown to benefit tissue repair in a variety of wound types, but variations in study designs, administration, and parameters render its application in clinical practice somewhat unconventional. A dressing was designed to generate an electric potential of 0.6 V to 0.7 V in the presence of moisture, thereby delivering a sustained micro-current without the need for an external power source. The purpose of this study was to examine the effects of this bio-electric dressing (BED) on deep, partial-thickness wounds using six female specific pathogen-free animals and a well established porcine model for wound healing. Wounds (10 mm × 7 mm × 0.5 mm) were created in paravertebral and thoracic areas of these animals using a specialized electrokeratome and covered with the active polyester BED and a polyurethane film dressing (n ≤ 30) (treatment) or an inactive polyester and film dressing (n ≤ 30). Using an epidermal migration assay, wounds were assessed daily from day 4 through day 8 post-wounding. Differ-ences in the proportion of wounds healed were statistically significant (P <0.001) on days 5 and 6 post-wounding. These results show BED is more effective than a control dressing treatment with moisture-retentive dressings in this animal model. Controlled clinical studies are warranted to elucidate the potential clinical implications of this treatment modality.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalOstomy Wound Management
Volume58
Issue number9
StatePublished - Sep 1 2012

Keywords

  • animal experimentation
  • electric stimulation
  • epithelium
  • occlusive dressings
  • wound healing

ASJC Scopus subject areas

  • Gastroenterology
  • Internal Medicine
  • Nursing(all)

Fingerprint Dive into the research topics of 'Efficacy of a bio-electric dressing in healing deep, partial-thickness wounds using a porcine model'. Together they form a unique fingerprint.

  • Cite this