Effects of Various Alpha-1 Antitrypsin Supplement Dosages on the Lung Microbiome and Metabolome

Trevor Cickovski, Astrid Manuel, Kalai Mathee, Michael Campos, Giri Narasimhan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Patients with Alpha-1 Antitrypsin Deficiency (A1AD) have abnormally low levels of the protein Alpha-1 Antitrypsin (AAT) in their blood, because of a double mutation that makes the protein misfold and instead collect in the liver (sometimes even causing cirrhosis). The currently accepted single dosage (SD) of AAT supplements does not produce AAT blood concentrations anywhere near normal levels; they typically only reach the effect of having a single mutation. Some have therefore advocated for a double dosage (DD) of these treatments, which generally would be enough to approach these normal concentrations. Levels of cytokines, produced by the immune system in response to an attack, have already been observed to drop dramatically when A1AD patients consuming single dosage started taking double dosage, and then either remain the same or increase again upon return to a single dosage regimen. In this study we administer the same dosage sequence to A1AD patients (SD, DD, SD) for one month each and view the effects on their lung microbiome and metabolome. We analyze both at the end of each stage, comparing and contrasting and discovering potential biomarkers for each stage, and concluding with a discussion of potential implications.

Original languageEnglish (US)
Title of host publicationComputational Advances in Bio and Medical Sciences - 9th International Conference, ICCABS 2019, Revised Selected Papers
EditorsIon Mandoiu, Sanguthevar Rajasekaran, T.M. Murali, Giri Narasimhan, Pavel Skums, Alexander Zelikovsky
PublisherSpringer
Pages90-101
Number of pages12
ISBN (Print)9783030461645
DOIs
StatePublished - 2020
Event9th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2019 - Miami, United States
Duration: Nov 15 2019Nov 17 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12029 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference9th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2019
CountryUnited States
CityMiami
Period11/15/1911/17/19

Keywords

  • Alpha-1 Antitrypsin Deficiency (A1AD)
  • Metabolome
  • Microbiome
  • Networks

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Cickovski, T., Manuel, A., Mathee, K., Campos, M., & Narasimhan, G. (2020). Effects of Various Alpha-1 Antitrypsin Supplement Dosages on the Lung Microbiome and Metabolome. In I. Mandoiu, S. Rajasekaran, T. M. Murali, G. Narasimhan, P. Skums, & A. Zelikovsky (Eds.), Computational Advances in Bio and Medical Sciences - 9th International Conference, ICCABS 2019, Revised Selected Papers (pp. 90-101). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 12029 LNBI). Springer. https://doi.org/10.1007/978-3-030-46165-2_8