Effects of TRH in Circulatory Shock and Central Nervous System Ischemia

JOHN W. HOLADAY, JOSEPH B. LONG, ALBERTO MARTINEZ‐ARIZALA, HUI‐SUN ‐S CHEN, DAVID G. REYNOLDS, NELSON J. GURLL

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Thyrotropin-releasing hormone (TRH) is an enormously versatile substance that has many pharmacological effects beyond its established hypophysiotrophic actions. Experimental evidence has accrued to indicate that TRH used as a drug may be a treatment of choice for anaphylactic shock, spinal injury, and amyotrophic lateral sclerosis and be used as an analeptic agent to reverse the effects of anesthetics. The potential use of TRH in the treatment of septic shock, hemorrhagic shock, and stroke remains to be further established. Nonetheless, several potent analogues of TRH are available, and each may offer a different pharmacological spectrum of action that should be evaluated in these clinically relevant disorders. Because TRH is enormously safe at large doses in animals and man, future clinical trials with TRH and its analogues may provide additional support for the further exploitation of these substances in clinical medicine.

Original languageEnglish (US)
Pages (from-to)370-379
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume553
Issue number1
DOIs
StatePublished - Mar 1989
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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