Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK

An experimental study

George D. Kymionis, Vasilios F. Diakonis, Spyridon Charisis, Aristofanis I. Pallikaris, Dimitrios I. Bouzoukis, Sonia H Yoo, Irine Naoumidi, Miltiadis K. Tsilimbaris

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PURPOSE: To investigate the effects of the application of mitomycin C (MMC) after photorefractive keratectomy (PRK) on the ciliary body and intraocular pressure (IOP) in an experimental model. METHODS: Forty eyes of 20 rabbits underwent PRK to correct -8;00 diopters (D) in a 5-mm optical zone. Sterile surgical sponges (5 mm) soaked with 0.02% MMC were applied to corneas with the epithelium removed. Eyes were randomly chosen to receive MMC for 2 minutes (study group), and sponges soaked with balanced salt solution were applied on the contralateral eye (control group) for 2 minutes. Histological evaluation of the ciliary body was perfonned in a masked fashion by light and transmission electron microscopy. RESULTS: Histological examination of the morphology of the ciliary body structures revealed no differences between the two groups. Tonometric measurements of the IOP remained stable during the follow-up period with no significant changes (P=.75). CONCLUSIONS: Adjuvant application of MMC after PRK does not appear to induce alterations on the ciliary body or changes in IOP measurements.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalJournal of Refractive Surgery
Volume24
Issue number6
StatePublished - Jun 1 2008

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Photorefractive Keratectomy
Ciliary Body
Mitomycin
Intraocular Pressure
Surgical Sponges
Porifera
Transmission Electron Microscopy
Cornea
Theoretical Models
Epithelium
Salts
Rabbits
Light
Control Groups

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kymionis, G. D., Diakonis, V. F., Charisis, S., Pallikaris, A. I., Bouzoukis, D. I., Yoo, S. H., ... Tsilimbaris, M. K. (2008). Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK: An experimental study. Journal of Refractive Surgery, 24(6), 633-638.

Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK : An experimental study. / Kymionis, George D.; Diakonis, Vasilios F.; Charisis, Spyridon; Pallikaris, Aristofanis I.; Bouzoukis, Dimitrios I.; Yoo, Sonia H; Naoumidi, Irine; Tsilimbaris, Miltiadis K.

In: Journal of Refractive Surgery, Vol. 24, No. 6, 01.06.2008, p. 633-638.

Research output: Contribution to journalArticle

Kymionis, GD, Diakonis, VF, Charisis, S, Pallikaris, AI, Bouzoukis, DI, Yoo, SH, Naoumidi, I & Tsilimbaris, MK 2008, 'Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK: An experimental study', Journal of Refractive Surgery, vol. 24, no. 6, pp. 633-638.
Kymionis GD, Diakonis VF, Charisis S, Pallikaris AI, Bouzoukis DI, Yoo SH et al. Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK: An experimental study. Journal of Refractive Surgery. 2008 Jun 1;24(6):633-638.
Kymionis, George D. ; Diakonis, Vasilios F. ; Charisis, Spyridon ; Pallikaris, Aristofanis I. ; Bouzoukis, Dimitrios I. ; Yoo, Sonia H ; Naoumidi, Irine ; Tsilimbaris, Miltiadis K. / Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK : An experimental study. In: Journal of Refractive Surgery. 2008 ; Vol. 24, No. 6. pp. 633-638.
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N2 - PURPOSE: To investigate the effects of the application of mitomycin C (MMC) after photorefractive keratectomy (PRK) on the ciliary body and intraocular pressure (IOP) in an experimental model. METHODS: Forty eyes of 20 rabbits underwent PRK to correct -8;00 diopters (D) in a 5-mm optical zone. Sterile surgical sponges (5 mm) soaked with 0.02% MMC were applied to corneas with the epithelium removed. Eyes were randomly chosen to receive MMC for 2 minutes (study group), and sponges soaked with balanced salt solution were applied on the contralateral eye (control group) for 2 minutes. Histological evaluation of the ciliary body was perfonned in a masked fashion by light and transmission electron microscopy. RESULTS: Histological examination of the morphology of the ciliary body structures revealed no differences between the two groups. Tonometric measurements of the IOP remained stable during the follow-up period with no significant changes (P=.75). CONCLUSIONS: Adjuvant application of MMC after PRK does not appear to induce alterations on the ciliary body or changes in IOP measurements.

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