Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK: An experimental study

George D. Kymionis, Vasilios F. Diakonis, Spyridon Charisis, Aristofanis I. Pallikaris, Dimitrios I. Bouzoukis, Sonia H. Yoo, Irine Naoumidi, Miltiadis K. Tsilimbaris

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

PURPOSE: To investigate the effects of the application of mitomycin C (MMC) after photorefractive keratectomy (PRK) on the ciliary body and intraocular pressure (IOP) in an experimental model. METHODS: Forty eyes of 20 rabbits underwent PRK to correct -8;00 diopters (D) in a 5-mm optical zone. Sterile surgical sponges (5 mm) soaked with 0.02% MMC were applied to corneas with the epithelium removed. Eyes were randomly chosen to receive MMC for 2 minutes (study group), and sponges soaked with balanced salt solution were applied on the contralateral eye (control group) for 2 minutes. Histological evaluation of the ciliary body was perfonned in a masked fashion by light and transmission electron microscopy. RESULTS: Histological examination of the morphology of the ciliary body structures revealed no differences between the two groups. Tonometric measurements of the IOP remained stable during the follow-up period with no significant changes (P=.75). CONCLUSIONS: Adjuvant application of MMC after PRK does not appear to induce alterations on the ciliary body or changes in IOP measurements.

Original languageEnglish (US)
Pages (from-to)633-638
Number of pages6
JournalJournal of Refractive Surgery
Volume24
Issue number6
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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