Effects of theophylline on urinary excretion of cyclic AMP, calcium, and phosphorus in normal subjects

A. A. Colin, Z. Kraiem, L. Kahana, Z. Hochberg

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The present study was designed to examine the effects of acute theophylline administration on urinary excretion of cyclic adenosine monophosphate (cAMP), calcium, and phosphorus in normal subjects. The results demonstrated that at therapeutic doses (5 mg i.v./kg body weight) theophylline exerted a distinct biologic effect on renal tubular activity in 5 normal subjects: an increase in nephrogenous cAMP accompanied by a rise in phosphate and calcium urinary excretion. Beyond the clinical implications, the data suggest that theophylline, in contrast to parathyroid hormone, may be acting via cAMP to exert both its phosphaturic and calciuric effect on renal tubules.

Original languageEnglish (US)
Pages (from-to)359-361
Number of pages3
JournalMineral and Electrolyte Metabolism
Volume10
Issue number6
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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