Effects of theophylline on urinary excretion of cyclic AMP, calcium, and phosphorus in normal subjects

Andrew Colin, Z. Kraiem, L. Kahana, Z. Hochberg

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The present study was designed to examine the effects of acute theophylline administration on urinary excretion of cyclic adenosine monophosphate (cAMP), calcium, and phosphorus in normal subjects. The results demonstrated that at therapeutic doses (5 mg i.v./kg body weight) theophylline exerted a distinct biologic effect on renal tubular activity in 5 normal subjects: an increase in nephrogenous cAMP accompanied by a rise in phosphate and calcium urinary excretion. Beyond the clinical implications, the data suggest that theophylline, in contrast to parathyroid hormone, may be acting via cAMP to exert both its phosphaturic and calciuric effect on renal tubules.

Original languageEnglish
Pages (from-to)359-361
Number of pages3
JournalMineral and Electrolyte Metabolism
Volume10
Issue number6
StatePublished - Dec 1 1984
Externally publishedYes

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Theophylline
Cyclic AMP
Phosphorus
Calcium
Kidney
Parathyroid Hormone
Body Weight
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Effects of theophylline on urinary excretion of cyclic AMP, calcium, and phosphorus in normal subjects. / Colin, Andrew; Kraiem, Z.; Kahana, L.; Hochberg, Z.

In: Mineral and Electrolyte Metabolism, Vol. 10, No. 6, 01.12.1984, p. 359-361.

Research output: Contribution to journalArticle

Colin, Andrew ; Kraiem, Z. ; Kahana, L. ; Hochberg, Z. / Effects of theophylline on urinary excretion of cyclic AMP, calcium, and phosphorus in normal subjects. In: Mineral and Electrolyte Metabolism. 1984 ; Vol. 10, No. 6. pp. 359-361.
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