Abstract
Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 4249-4254 |
| Number of pages | 6 |
| Journal | Oncogene |
| Volume | 23 |
| Issue number | 24 |
| DOIs | |
| State | Published - May 24 2004 |
| Externally published | Yes |
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Keywords
- AML
- AML1-ETO
- Stem cell biology
- Transcription factors
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
- Genetics
Cite this
Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells. / Nimer, Stephen D; Moore, Malcolm A S.
In: Oncogene, Vol. 23, No. 24, 24.05.2004, p. 4249-4254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells
AU - Nimer, Stephen D
AU - Moore, Malcolm A S
PY - 2004/5/24
Y1 - 2004/5/24
N2 - Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.
AB - Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.
KW - AML
KW - AML1-ETO
KW - Stem cell biology
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=2942520981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942520981&partnerID=8YFLogxK
U2 - 10.1038/sj.onc.1207673
DO - 10.1038/sj.onc.1207673
M3 - Article
C2 - 15156180
AN - SCOPUS:2942520981
VL - 23
SP - 4249
EP - 4254
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 24
ER -