Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells

Stephen D Nimer, Malcolm A S Moore

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.

Original languageEnglish
Pages (from-to)4249-4254
Number of pages6
JournalOncogene
Volume23
Issue number24
DOIs
StatePublished - May 24 2004
Externally publishedYes

Fingerprint

Hematopoietic Stem Cells
Leukemia
Myeloproliferative Disorders
Genetic Translocation
Proteins
Regulator Genes
Protein-Tyrosine Kinases
Maintenance
Genes

Keywords

  • AML
  • AML1-ETO
  • Stem cell biology
  • Transcription factors

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells. / Nimer, Stephen D; Moore, Malcolm A S.

In: Oncogene, Vol. 23, No. 24, 24.05.2004, p. 4249-4254.

Research output: Contribution to journalArticle

@article{3edb18f14bae44c89b6b52bfb4491c30,
title = "Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells",
abstract = "Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.",
keywords = "AML, AML1-ETO, Stem cell biology, Transcription factors",
author = "Nimer, {Stephen D} and Moore, {Malcolm A S}",
year = "2004",
month = "5",
day = "24",
doi = "10.1038/sj.onc.1207673",
language = "English",
volume = "23",
pages = "4249--4254",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "24",

}

TY - JOUR

T1 - Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells

AU - Nimer, Stephen D

AU - Moore, Malcolm A S

PY - 2004/5/24

Y1 - 2004/5/24

N2 - Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.

AB - Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myclogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloproliferative disorders tyrosine kinases are frequently involved. These rearrangements alter the function of at least one and often both of the involved genes. In this review, we focus on the AML1-ETO (a.k.a. RUNX1-ETO) fusion protein, which is found in t(8;21) + AML. Expression of AML1-ETO in human hematopoietic stem cells (HSCs) preferentially enhances their maintenance, as opposed to their differentiation. The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed.

KW - AML

KW - AML1-ETO

KW - Stem cell biology

KW - Transcription factors

UR - http://www.scopus.com/inward/record.url?scp=2942520981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942520981&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1207673

DO - 10.1038/sj.onc.1207673

M3 - Article

VL - 23

SP - 4249

EP - 4254

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 24

ER -