Effects of the cyclooxygenase inhibitor ibuprofen on retinal and choroidal blood flow during hyperoxia in newborn piglets

Tom A. Stiris, Cleide Suguihara, John Flynn, Jose Quero, Eduardo Bancalari

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The effect of the cyclooxygenase inhibitor ibuprofen (IB) on choroidal (ChBF) and retinal (RBF) blood flow during hyperoxia was examined in 21 spontaneously breathing newborn piglets. Methods: ChBF and RBF were measured using radiolabelled microspheres before and 30 min after either saline or IB (30 mg/kg, IV) infusion in room air and subsequently, after 90 min of hyperoxia (O 2). Results: The basal RBF and ChBF did not change after IB infusion. However, during hyperoxia a significant decrease in RBF was observed in the IB group (54 ± 5 to 37 ± 3 ml/min/100 g, p < 0.02) and in the control group (54 ± 3 to 37 ± 5 ml/min/100 g, p < 0.02). Also, ChBF decreased in the IB group (2,635 ± 446 to 1,670 ± 199 ml/min/100 g, p < 0.02) and in the control group, (2,997 ± 346 to 2,014 ± 246 ml/min/100 g, p < 0.02) during hyperoxia. Conclusions: Despite cyclooxygenase inhibition with IB, RBF and ChBF decreased to the same extent as in the control group following exposure to O 2. These data suggest that hyperoxia decrease RBF and ChBF through mechanisms and/or mediators other than the cyclooxygenase by-products of arachidonic acid metabolism.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalNeonatology
Volume69
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • Arachidonic acid metabolites
  • Blood flow
  • Eye
  • Hyperoxia
  • Ibuprofen
  • Oxygen
  • Retina
  • Retinopathy of prematurity

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Effects of the cyclooxygenase inhibitor ibuprofen on retinal and choroidal blood flow during hyperoxia in newborn piglets'. Together they form a unique fingerprint.

  • Cite this