Abstract
Purpose of Review: While early studies suggested that testosterone replacement therapy would enlarge the prostate and worsen lower urinary tract symptoms, this review seeks to examine the combined evidence of observational studies, randomized control trials, and meta-analyses published on the topic to determine if testosterone replacement therapy worsens lower urinary tract symptoms in hypogonadal men. Recent Findings: The combined evidence of 15 randomized control trials and 2 meta-analyses has demonstrated emphatically that testosterone replacement therapy has no effect on lower urinary tract symptoms in hypogonadal men with mild and moderate symptoms. Summary: No randomized control trial has sufficiently examined the effect of testosterone replacement therapy in men with severe lower urinary tract symptoms. While a few observational studies have seen no effect when hypogonadal men with severe lower urinary tract symptoms are treated with testosterone replacement therapy, future randomized controlled trials specifically studying the effect of testosterone on men with severe lower urinary tract symptoms are warranted. In summary, clinicians should rest assured that testosterone does not worsen lower urinary tract symptoms in hypogonadal men with mild or moderate lower urinary tract symptoms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 118-123 |
| Number of pages | 6 |
| Journal | Current Bladder Dysfunction Reports |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2017 |
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Keywords
- Benign prostatic hyperplasia
- Hypogonadism
- Lower urinary tract symptoms
- Prostate
- Testosterone
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
Cite this
Effects of Testosterone Replacement Therapy on Lower Urinary Tract Symptoms. / Kohn, Grace E.; Kohn, Taylor P.; Ramasamy, Ranjith.
In: Current Bladder Dysfunction Reports, Vol. 12, No. 2, 01.06.2017, p. 118-123.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Effects of Testosterone Replacement Therapy on Lower Urinary Tract Symptoms
AU - Kohn, Grace E.
AU - Kohn, Taylor P.
AU - Ramasamy, Ranjith
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Purpose of Review: While early studies suggested that testosterone replacement therapy would enlarge the prostate and worsen lower urinary tract symptoms, this review seeks to examine the combined evidence of observational studies, randomized control trials, and meta-analyses published on the topic to determine if testosterone replacement therapy worsens lower urinary tract symptoms in hypogonadal men. Recent Findings: The combined evidence of 15 randomized control trials and 2 meta-analyses has demonstrated emphatically that testosterone replacement therapy has no effect on lower urinary tract symptoms in hypogonadal men with mild and moderate symptoms. Summary: No randomized control trial has sufficiently examined the effect of testosterone replacement therapy in men with severe lower urinary tract symptoms. While a few observational studies have seen no effect when hypogonadal men with severe lower urinary tract symptoms are treated with testosterone replacement therapy, future randomized controlled trials specifically studying the effect of testosterone on men with severe lower urinary tract symptoms are warranted. In summary, clinicians should rest assured that testosterone does not worsen lower urinary tract symptoms in hypogonadal men with mild or moderate lower urinary tract symptoms.
AB - Purpose of Review: While early studies suggested that testosterone replacement therapy would enlarge the prostate and worsen lower urinary tract symptoms, this review seeks to examine the combined evidence of observational studies, randomized control trials, and meta-analyses published on the topic to determine if testosterone replacement therapy worsens lower urinary tract symptoms in hypogonadal men. Recent Findings: The combined evidence of 15 randomized control trials and 2 meta-analyses has demonstrated emphatically that testosterone replacement therapy has no effect on lower urinary tract symptoms in hypogonadal men with mild and moderate symptoms. Summary: No randomized control trial has sufficiently examined the effect of testosterone replacement therapy in men with severe lower urinary tract symptoms. While a few observational studies have seen no effect when hypogonadal men with severe lower urinary tract symptoms are treated with testosterone replacement therapy, future randomized controlled trials specifically studying the effect of testosterone on men with severe lower urinary tract symptoms are warranted. In summary, clinicians should rest assured that testosterone does not worsen lower urinary tract symptoms in hypogonadal men with mild or moderate lower urinary tract symptoms.
KW - Benign prostatic hyperplasia
KW - Hypogonadism
KW - Lower urinary tract symptoms
KW - Prostate
KW - Testosterone
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U2 - 10.1007/s11884-017-0419-2
DO - 10.1007/s11884-017-0419-2
M3 - Review article
AN - SCOPUS:85019762424
VL - 12
SP - 118
EP - 123
JO - Current Bladder Dysfunction Reports
JF - Current Bladder Dysfunction Reports
SN - 1931-7212
IS - 2
ER -