Effects of swelling pressure and hydraulic permeability on dynamic compressive behavior of lumbar annulus fibrosus

Hai Yao, Marc Antoine Justiz, Daniel Flagler, Weiyong Gu

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The effects of proteoglycan (PG) loss on the mechanical properties of annulus fibrosus (AF) in compression were studied for the purpose of understanding the role of swelling pressure in supporting a dynamic compressive load in the intervertebral disk (IVD). Eleven lumbar disk specimens were used as the control group and the other paired eleven were treated with the trypsin enzyme. All the specimens were tested to determine the swelling pressure, equilibrium and dynamic moduli, hydraulic permeability, water content, wet tissue, and dry tissue density. In general, evidence was obtained that the swelling pressure plays an important role in supporting the externally applied compressive load under static and dynamic loading conditions.

Original languageEnglish
Pages (from-to)1234-1241
Number of pages8
JournalAnnals of Biomedical Engineering
Volume30
Issue number10
DOIs
StatePublished - Dec 1 2002

Fingerprint

Swelling
Hydraulics
Tissue
Water content
Enzymes
Mechanical properties
Proteoglycans

Keywords

  • Annulus fibrosus
  • Dynamic modulus
  • Hydraulic permeability
  • Intervertebral disk
  • Spine
  • Swelling pressure
  • Tissue biomechanics

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Effects of swelling pressure and hydraulic permeability on dynamic compressive behavior of lumbar annulus fibrosus. / Yao, Hai; Justiz, Marc Antoine; Flagler, Daniel; Gu, Weiyong.

In: Annals of Biomedical Engineering, Vol. 30, No. 10, 01.12.2002, p. 1234-1241.

Research output: Contribution to journalArticle

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