Sulindac and indomethacin were tested over the short term for their effect on the renin-aldosterone system in 9 patients on a low-sodium diet. Neither aldosterone nor renin were suppressed by sulindac. Both renin and aldosterone decreased after indomethacin. Postural changes in renin and aldosterone were not altered by either drug. The excretion rate of aldosterone was unaltered by either drug. Serum potassium increased in 2 patients on indomethacin. Sulindac appears to have a smaller suppressant effect than indomethacin on the renin-aldosterone system.
|Original language||English (US)|
|Number of pages||6|
|Journal||Current Therapeutic Research - Clinical and Experimental|
|State||Published - Jan 1 1985|
ASJC Scopus subject areas
- Pharmacology (medical)