Submicronic aerosol of sulfuric acid (H 2SO 4) originates from the burning of fossil fuels and discharge of vapor from the automobile engine equipped with the catalytic converter. This study was conducted to determine whether brief exposure to this aerosol in high concentrations adversely affects the cardiopulmonary system. In all studies, submicronic aerosol of sodium chloride was used as a control. Anesthetized dogs that breathed H 2SO 4 aerosol in concentrations up to 8 mg per m 3 showed no effects on respiratory resistance, static lung compliance, and functional residual capacity. A 4-hour exposure to H 2SO 4 aerosol (4 mg per m 3) produced no significant changes in mechanics of breathing, functional residual capacity, pulmonary and systemic arterial blood pressure, cardiac output, heart rate, and arterial blood gas tensions. Conscious sheep that breathed H 2SO 4 aerosol in concentrations up to 14 mg per m 3 for 20 min had no alteration of tracheal mucous velocity in an immediate 3-hour follow-up period or 5 to 10 days later. Conscious sheep that breathed H 2SO 4 aerosol (4 mg per m 3) for 4 hours had no significant alteration of tracheal mucous velocity immediately and 2 hours thereafter. Both normal and asthmatic adults breathing H 2SO 4 aerosol in concentrations up to 1 mg per m 3 for 10 min showed no significant alteration of lung volumes, distribution of ventilation, ear oximetry, dynamic mechanics of breathing, oscillation mechanics of the chest-lung system, pulmonary capillary blood flow, diffusing capacity, O 2 consumption, and pulmonary tissue volume. No delayed effects in pulmonary function nor exacerbation of bronchial asthma were observed during a follow-up period of a few weeks. The present study indicates that single exposure to submicronic H 2SO 4 aerosol does not produce an immediate or a delayed adverse effect on cardiopulmonary function in anesthetized dogs, conscious sheep, and normal and asthmatic adults.
|Original language||English (US)|
|Number of pages||14|
|Journal||American Review of Respiratory Disease|
|State||Published - Dec 1 1978|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine