Effects of somatostatin-14 and somatostatin-28 on plasma hormonal and gastric secretory responses to cephalic and gastrointestinal stimulation in man

S. J. Konturek, N. Kwiecie, W. Obtuowicz, W. Bielaski, J. Oleksy, A. V. Schally

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

This study was designed to determine the influence of cephalic and gastrointestinal meal stimulation on plasma levels of somatostatin-like immunoreactivity (SLI) and to compare plasma hormonal and gastric secretory effects of somatostatin-14 (SS-14) and its putative prohormone, somatostatin-28 (SS-28), in humans. Cephalic stimulation induced by modified sham feeding did not affect plasma SLI, whereas a gastric liver extract meal caused a significant increase in SLI. Infusion of SS-28 dose-dependently suppressed gastric acid, serum gastrin, and plasma pancreatic polypeptide (PP) responses to cephalic and gastrointestinal stimulation. SS-28 was equipotent with SS-14 as gastric inhibitor when compared on the basis of molar doses infused but was 4-10 times less potent on the basis of plasma SLI concentrations obtained. A lower and more physiological dose of SS-14 (75 pmol/kg-h) reduced gastric acid and PP responses but failed to affect the serum gastrin response to a meal, whereas a larger, pharmacological dose (500 pmol/kg-h) also suppressed serum gastrin responses. We conclude that meal releases SLI into the circulation and that SS-28 mimics the gastric secretory and plasma hormonal effects of SS-14 but is several times less potent than SS-14 in terms of circulating hormone levels.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalScandinavian Journal of Gastroenterology
Volume20
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

    Fingerprint

Keywords

  • Cephalic phase
  • Gastric secretion
  • Gastrointestinal hormones
  • Somatostatin

ASJC Scopus subject areas

  • Gastroenterology

Cite this