Effects of sodium cyanate in mice bearing B16 melanoma

Michael A. Lea, Aleykutty Luke, Omaida Velazquez, Leah Carpenter, Charles F. Martinson, Helene Z. Hill, George J. Hill

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Sodium cyanate injected IP at a dose level of 200 or 250 mg/kg caused a 90% or greater inhibition of the incorporation of [3H]thymidine into DNA of B16 melanoma transplanted SC in mice. Despite the inhibitory effect of sodium cyanate on precursor incorporation into DNA, no significant effect on host survival was observed when sodium cyanate was administered as a single agent in the diet, in drinking water, or by IP injection to mice that had received IP transplants of B16 melanoma. The action of melphalan and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in prolonging the survival time of melanoma-bearing mice was not enhanced by combined treatment with sodium cyanate. However, combined injections of sodium cyanate and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) increased the survival of tumor-bearing mice significantly more than injections of BCNU alone at a lower dose than the maximum tolerated one. These data and other studies suggest that B16 melanoma may be less responsive to the action of sodium cyanate than are murine leukemic cells or rat hepatomas.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalCancer Chemotherapy And Pharmacology
Volume17
Issue number3
DOIs
StatePublished - Jul 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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  • Cite this

    Lea, M. A., Luke, A., Velazquez, O., Carpenter, L., Martinson, C. F., Hill, H. Z., & Hill, G. J. (1986). Effects of sodium cyanate in mice bearing B16 melanoma. Cancer Chemotherapy And Pharmacology, 17(3), 231-235. https://doi.org/10.1007/BF00256690