Effects of short- and long-term haloperidol administration and withdrawal on regional brain cholecystokinin and neurotensin concentrations in the rat

James M. Radke, A. John MacLennan, Margery C. Beinfeld, Garth Bissette, Charles Nemeroff, Steven R. Vincent, Hans C. Fibiger

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The effects of oral administration of the neuroleptic, haloperidol, on regional brain concentrations of cholecystokinin (CCK) and neurotensin were examined in the rat. Both short-term (3 weeks) and long-term (8 months) haloperidol administration increased the concentration of CCK inthe substantia nigra. While short-term administration significantly increased the concentration of CCK in the ventral tegmental area and decreased the concentration of CCK in the cortex, including the medial prefrontal cortex, these effects were not observed following long-term drug administration. In contrast, long-term, but not short-term, haloperidol administration decreased the concentration of CCK in the olfactory tubercle. Withdrawal from long-term haloperidol did not alter CCK concentrations in any of the brain regions examined. Short-term haloperidol administration significantly increased the concentration of neurotensin in the caudate-putamen. Both short- and long-term administration increased the concentration of neurotensin in the nucleus accumbens, but only the increase following long-term administration reached statistical significance. Withdrawal from long-term haloperidol administration slightly decreased the concentrations of neurotensin in the caudate-putamen and nucleus accumbens. These results indicate that dopamine receptor blockade can affect both CCK- and neurotensin-containing neural systems. Furthermore, these two neuropeptides are affected differently depending upon the duration of haloperidol administration and withdrawal from this drug. The results raise the possibility that chronic administration of haloperidol may be toxic to some neurotensin-containing neurons in the basal ganglia.

Original languageEnglish
Pages (from-to)178-183
Number of pages6
JournalBrain Research
Volume480
Issue number1-2
DOIs
StatePublished - Feb 20 1989
Externally publishedYes

Fingerprint

Neurotensin
Cholecystokinin
Haloperidol
Brain
Putamen
Nucleus Accumbens
Ventral Tegmental Area
Caudate Nucleus
Poisons
Dopamine Receptors
Substantia Nigra
Basal Ganglia
Prefrontal Cortex
Neuropeptides
Pharmaceutical Preparations
Antipsychotic Agents
Oral Administration
Neurons

Keywords

  • Cholecystokinin
  • Dopamine
  • Haloperidol
  • Neurotensin
  • Rat

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effects of short- and long-term haloperidol administration and withdrawal on regional brain cholecystokinin and neurotensin concentrations in the rat. / Radke, James M.; MacLennan, A. John; Beinfeld, Margery C.; Bissette, Garth; Nemeroff, Charles; Vincent, Steven R.; Fibiger, Hans C.

In: Brain Research, Vol. 480, No. 1-2, 20.02.1989, p. 178-183.

Research output: Contribution to journalArticle

Radke, James M. ; MacLennan, A. John ; Beinfeld, Margery C. ; Bissette, Garth ; Nemeroff, Charles ; Vincent, Steven R. ; Fibiger, Hans C. / Effects of short- and long-term haloperidol administration and withdrawal on regional brain cholecystokinin and neurotensin concentrations in the rat. In: Brain Research. 1989 ; Vol. 480, No. 1-2. pp. 178-183.
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